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Lycopodium Alkaloids: Lycoplatyrine A, an Unusual Lycodine-Piperidine Adduct from Lycopodium platyrhizoma and the Absolute Configurations of Lycoplanine D and Lycogladine H.
Journal of Natural Products ( IF 5.1 ) Pub Date : 2019-01-30 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00754
Joanne Soon-Yee Yeap 1 , Kuan-Hon Lim 2 , Kien-Thai Yong 3 , Siew-Huah Lim 1 , Toh-Seok Kam 1 , Yun-Yee Low 1
Affiliation  

Three new Lycopodium alkaloids comprising two lycodine-type alkaloids (1, 2) and one fawcettimine alkaloid (3), in addition to 16 known alkaloids, were isolated from Lycopodium platyrhizoma. The structures of these alkaloids were elucidated based on analysis of their NMR and MS data. Lycoplatyrine A (1) represents an unusual lycodine–piperidine adduct. The structures and absolute configurations of lycoplanine D (hydroxy-des-N-methyl-α-obscurine, 10) and lycogladine H (11) were confirmed by X-ray diffraction analysis.

中文翻译:

枸杞碱生物碱:番荔枝碱A,一种来自于扁柏石蕊的不常见的番荔枝碱-哌啶加合物,以及番荔枝碱D和Lycogladine H的绝对构型。

三个新的石松包括两个lycodine型生物碱(生物碱12)和一个fawcettimine生物碱(3)中,除了16种已知的生物碱,是从分离石松platyrhizoma。根据对它们的NMR和MS数据进行分析,阐明了这些生物碱的结构。莱铂碱A(1)代表一种不常见的莱考定-哌啶加合物。通过X射线衍射分析确认了莱考普宁D(羟基-des- N-甲基-α-obscurine,10)和莱考格拉定H(11)的结构和绝对构型。
更新日期:2019-01-30
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