Five new iridoid glucoside derivatives (1–5), three new diterpenoids (7, 12, and 15), and 11 known compounds were isolated from the aqueous EtOH extract of Caryopteris glutinosa. Cell-based estrogen biosynthesis assays indicated that caryopteriside C (3) and caryopterisoid B (12) promote the biosynthesis of estrogen E2, with EC₅₀ values of 11.1 and 8.0 μM, respectively, in human ovarian granulosa-like KGN cells via upregulating the expression of aromatase.

中文翻译：

---

环烯醚萜苷和二萜从莸黄

五个新的环烯醚萜苷衍生物（15），三个新的二萜类化合物（7，12，和15），和11种已知的化合物从的EtOH水溶液提取物中分离莸黄。基于细胞的雌激素生物合成测定结果表明，鳞翅类药物C（3）和类胡萝卜素B（12）促进雌激素E2的生物合成，通过上调表达，在人卵巢颗粒样KGN细胞中的EC ₅₀值分别为11.1和8.0μM。芳香化酶。