UNIT-V.pdf

Study of Biological Source, Chemical Nature and Uses of Drugs
of Natural Origin Containing Drugs
Prepared by
Mr. A. K. Daswad
Asst. Professor
Nanded Pharmacy College (Degree), Nanded
UNIT-V

CONTENTS
➢ PLANT PRODUCTS:
Fibres - Cotton, Jute, Hemp
Hallucinogens, Teratogens, Natural allergens
➢ PRIMARY METABOLITES:
Pharmaceutical Aids and/or Medicines for the following Primary metabolites:
▪ Carbohydrates: Acacia, Agar, Tragacanth, Honey
▪ Proteins and Enzymes : Gelatin, Casein, Proteolytic enzymes (Papain,
bromelain, Serratiopeptidase, Urokinase, Streptokinase, Pepsin).
▪ Lipids (Waxes, Fats, Fixed Oils) : Castor oil, Chaulmoogra oil, Wool Fat,
Bees Wax
➢ MARINE DRUGS:
Novel medicinal agents from marine sources

➢ Tissue composed of Spindle shaped or elongated thick walled
cells with pointed ends, cell walls of which consist of cellulose
and may or may not contain lignin.
➢ Fibers are developed from single cell, the fibers initial, which
during its development grows rapidly in the axial direction.
➢ They are unicellular in structure.
➢During its growth period, the tips of the elongating cells may
push one another. This process is known as “Gliding growth.”
PLANT PRODUCTS
Fibres

➢ On the basis of tissue in which they occur they are diffrentiated as:
✓Pericyclic fibres
✓Phloem fibres
✓Xylem fibres
✓ Pericyclic fibres: They are found in the pericyclic region i.e. near
xylem and phloem. May or may not be lignified.
✓ Pholem fibres: They are found in the phloem region May or may not
be lignified.
✓ Xylem fibres: They are found in the xylem region. They are dead and
always lignified elements.
Differentiation of fibres

Fibres
Natural Artificial
Plant Animal Mineral
Cotton, Jute,
Hemp,
Flax, Banana
Wool, Silk
Glass,
Asbestos
Regenerated Synthetic
Carbohydrate
Protein
Alginate yarrn,
viscose rayon,
Proxyline,
Acetated Rayon
Nylone,
terylene
Aridil, Fibroline
Classification of fibers

1. Microscopical examination
2. Physical test like ignition test
3. Various chemical test are done like
Molisch’s Test: Sample + α-napthol in alcohol and
conc. Sulphuric acid Violet colour- Plant
and regenerated fibres present
Million’s Test:
Sample + Millon’s reagent + Warm
Animal fibres present
Red colour-
Identification of fibres

COTTON
• SYNONYM:-
Raw cotton or absorbent cotton, surgical cotton, purified cotton
• BIOLOGICAL SOURCE:
Cotton consist of the epidermal trichomes or hairs of the seeds of
cultivated species of the Gossypium barbadense , G. Herbaceum, G.
Herbaceurre, G. Hirsutum.
• FAMILY: Malvaceae
• GEOGRAPHICAL SOURCE:- Africa, South Africa, USA, Egypt,
India.

➢ Seeds are covered with the hairs are known as Bolls.
➢They are collected, dried and taken to ginning press where
trichomes are separated from the seeds.
➢ Various devices are used to separate the hairs.
➢The short and long hairs are separated from each other. The hairs
with short length are know as Linters and used for the manufacture
of absorbent cotton
➢ While long hairs are used for the preparation of cloth.
➢The raw cotton obtained by this way is full of impurities like wax,
fat, coloring matter, vegetable debris etc.
Cotton Preparation

➢It is processed to get rid of most of the impurities.
➢It is taken to the machine known as cotton opener and followed by
treatment with dilute soda solution or soda ash solution under pressure for
about 10-15 hours.
➢The wax, fatty material and coloring matter are removed by this
treatment.
➢It is then washed with water and treated with suitable bleaching
agent.
➢It is again washed with water, dried and carded into flat sheets.
➢It is finally packed in wrappers and sterilized by means of Gamma
radiations.
Cotton Preparation

➢Size- 2.5 to 4.5 cm in length and 25 to 35µ in
diameter.
➢Shape- Cylindrical when young, but becomes
flattened and twisted as it matures
➢Colour- white (Due to bleaching), Slightly off white if sterilized
➢ Odour- Odourless
➢ Taste- Tasteless
➢Extra features: Appearance is soft, fine, filament like hairs
which are unicellular
Morphological Description

➢The trichomes are unicellular, flattened and ribbon
like with slightly thickened and rounded apex.
➢They are tubular and hollow.
Microscopical Characters

Chemical Constituents
➢ 90% of cellulose,
➢ 7-8% of moisture,
➢ 0.4% wax, fat, oil,
➢ 0.6% protoplasm and other cell content and
➢ 0.2% ash.
➢ Purified cotton or absorbent cotton is entirely
cellulose with 6-7% of moisture and 0.2-0.3% ash.

1. Specific test for cotton:- Cotton fibres + N/50
iodine Solution+ dry it + add few ml. of 80%
sulfuric acid Trichomes assume purplish-blue
hemp, wool, silk, nylon, alginate
or bluish-green colour (Distinction from
yarn
jute,
and
acetate rayon)
2. Cuoxam test:- Raw cotton fibres + Ammonical
oxide solution (cuoxam-reagent)
raw cotton fibres with formation of
copper
dissolves
balloons, while absorbent cotton dissolves
completely with uniform swelling.
CHEMICAL TESTS

3.Cotton + dilute sodium hydroxide solution and HCl
Insoluble (Distinction from silk).
4.Cotton + Cold 80% of sulfuric acid Soluble. And
insoluble in cold 60% sulfuric acid, Conc. HCl, 5%
KOH, 90% phenol, cresol, acetone
CHEMICAL TESTS

USES
➢ Filtering medium and surgical dressings.
➢ Insulating material
➢ Absorbent cotton absorbs blood, mucus, pus and
prevents the wounds from infections.

➢ store in cool place.
➢ The absorbent cotton should be wrapped in
wrappers so as to prevent the dust and
microbial contamination.
STORAGE

Hemp
➢ Synonyms: Cannabis Indica, Indian hemp,
Ganja, Marihuana, Charas.
➢ Biological source:
Hemp fibre is obtained from the bast of the
plant Cannabis sativa
➢ Family: Cannabinaceae.

Cultivation
➢ There are broadly three groups of Cannabis
varieties being cultivated today:
✓ Varieties primarily cultivated for
characterized by long stems
their
and
fibre,
little
branching, called industrial hemp.
✓ Varieties grown for seed from which hemp oil
is extracted.
✓ Varieties grown for medicinal or
recreational purposes.

Preparation & Morphology
➢ Fibres are obtained by subjecting the stalks to a series of
operations—including retting, drying, and crushing—
and a shaking process
➢ that completes separation from the woody portion,
releasing the long, fairly straight fibre, or line.
➢ The fibre strands, usually over 1.8 metres (5.8 feet)
long, are made of individual cylindrical cells with an
irregular surface.
➢ The fibre diameter ranges from 16 to 50 microns.
➢ The fibre, longer and less flexible, is usually yellowish,
greenish, or a dark brown or gray and, because it is not
easily bleached to sufficiently light shades, is rarely
dyed.

• Long, strong and durable, hemp fibres are about
70% cellulose and contain low levels of lignin
(around 8-10%).
• Pectin-2.9%
• Fat-Wax-0.9%
• Mineral-1.8%

Uses
• Hemp has been used for centuries to make rope,
canvas and paper
• Cloth
• Filter

Jute
• Synonym :- Gunny.
• BIOLOGICAL SOURCE:
• It consists of phloem fibres
from the stem of various
species of the Corchorus; C.
capsularis Linn, C. olitorius
Linn, and other species like
C. cunninghamii, C. junodi
etc., belonging to
• family :- Tiliaceae.

➢Geographical Source :-
✓West Bengal and Assam.
➢Description :-
✓ They are tall, usually annual herbs.
✓ Reaching to a height of 2–4 m, unbranched and if
branched it has only a few side branches.
✓ The leaves are alternate, simple, lanceolate, 5–15 cm
long and a finely serrated or lobed margin.
✓ The flowers are small (1.5–3 cm in diameter) and
yellow, with five petals;
✓ The fruit encloses many seeds in the capsule
Jute

Jute: Preparation
➢ Retting is the process for the preparation of bast fibres.
➢ This process is done by three methods,
✓ Microbial (or Water),
✓ Steam
✓ Mechanical Process.
➢ The microbial or water retting process is the oldest and
the popular method employed for the breaking of lignin
bond present between parenchyma and sclerenchyma.
➢ The breaking of this bond facilitates the easy procurement
of skin from its core.
➢ Then the material is washed dried to release pectin bond
which makes the hard skin to fine thread like fibres.
➢ The jute fibres are graded according to its colour, strength
and fibre length.
➢ The fibres are of white to brown and 1–4 m. long

Jute
• Microscopy :-
✓A thin transverse section of the strand when
treated with phuloroglucinol and HCl, stains the
strands deep red, indicating the presence of lignin.

➢ Cellulose → 50-53%
➢ Hemi-cellulose → 20%
➢ Lignin → 12-13%
➢ Water Soluble matter → 1.5%
➢ Fat and Wax → 1 % each

Jute: Uses
➢ It is listed as the second most important vegetable
fibre after cotton.
➢ Jute is used chiefly to make cloth for wrapping bales
of raw cotton, in the preparation of sacks and coarse
cloth.
➢ They are also woven into curtains, chair coverings,
carpets,
➢ Hessian cloth very fine threads of jute can be made
into imitation silk and also in the making of paper.
➢ It is even used in the manufacture of tows, padding
splints, filtering, and straining medium.
➢ Jute is used for the preparation of coarse bags.

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