Rubia yunnanensis
Species
KNApSAcK Entry
| Organism name | Rubia yunnanensis |
|---|---|
| Genus | Rubia |
| Family | Rubiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Rubia |
|---|---|
| Linked NCBI taxonomy ID | 25473 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Rubiaceae |
|---|---|
| ID | 24966 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (37)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001024
|
Baicalin
/ Baicalein 7-glucuronide |
CHEMBL485818
CHEMBL1447301 |
C038044
|
41 / 22 / 18 | 9 / 7 | No. 2 | No. 15 |
|
|
C00046364
|
Rubiarboside G
|
No. 32 | No. 51 |
|
||||
|
C00002828
|
2-Hydroxymethylanthraquinone
|
CHEMBL21049
|
No. 41 | No. 62 |
|
|||
|
C00032518
|
Xanthopurpurin
|
CHEMBL372711
|
2 / 0 / 7 | No. 41 | No. 62 |
|
||
|
C00002862
|
Rubiadin
/ 1,3-Dihydroxy-2-methyl-9,10-anthraquinone |
CHEMBL251251
|
C072500
|
No. 41 | No. 62 |
|
||
|
C00031546
|
6-Hydroxyrubiadin
/ 1,3,6-Trihydroxy-2-methylanthraquinone / 2-Methyl-1,3,6-trihydroxyanthraquinone / 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone |
CHEMBL251491
|
No. 41 | No. 62 |
|
|||
|
C00031526
|
1-Hydroxy-2-methylanthraquinone
/ 1-Hydroxy-2-methyl-9,10-anthraquinone |
CHEMBL42302
|
2 / 2 / 1 | No. 41 | No. 62 |
|
||
|
C00031244
|
Rubianthraquinone
|
No. 41 | No. 62 |
|
||||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00023774
|
Fucostanol
/ Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00046363
|
Rubiarboside A
|
No. 99 |
|
|||||
|
C00031241
|
Rubianoside II
|
No. 99 |
|
|||||
|
C00031240
|
Rubianoside I
|
CHEMBL445475
|
No. 99 |
|
||||
|
C00031242
|
Rubianoside III
|
No. 99 |
|
|||||
|
C00031243
|
Rubianoside IV
|
No. 99 |
|
|||||
|
C00031136
|
RA XII
|
CHEMBL1288990
|
C081563
|
No. 497 |
|
|||
|
C00031234
|
Rubianol a
|
CHEMBL467417
|
No. 681 |
|
||||
|
C00031238
|
Rubianol e
|
CHEMBL506046
|
No. 681 |
|
||||
|
C00031239
|
Rubianol g
|
No. 681 |
|
|||||
|
C00031237
|
Rubianol d
/ (+)-Rubianol d |
CHEMBL499320
|
No. 681 |
|
||||
|
C00031236
|
Rubianol c
|
CHEMBL462905
|
No. 681 |
|
||||
|
C00031235
|
Rubianol b
|
CHEMBL460714
|
No. 681 |
|
||||
|
C00045048
|
Rubiarbonone C
|
No. 681 |
|
|||||
|
C00046362
|
Rubiarbonone F
/ (+)-Rubiarbonone F |
No. 681 |
|
|||||
|
C00046361
|
Rubiarbonone D
/ (+)-Rubiarbonone D |
No. 681 |
|
|||||
|
C00046360
|
Rubiarbonol G
|
CHEMBL1835960
|
No. 681 |
|
||||
|
C00046359
|
Rubiarbonol B
|
CHEMBL484022
|
No. 681 |
|
||||
|
C00046358
|
Rubiarbonol A
|
CHEMBL467405
|
No. 681 |
|
||||
|
C00045047
|
Rubiarbonone B
|
CHEMBL511777
|
No. 681 |
|
||||
|
C00000602
|
(+)-Lariciresinol
|
CHEMBL518421
|
2 / 1 / 1 | No. 700 | No. 21 |
|
||
|
C00002682
|
Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid |
CHEMBL120568
|
D014641
|
5 / 3 / 3 | 5 / 0 | No. 1073 |
|
|
|
C00031248
|
Rubinaphthin A
/ (-)-Rubinaphthin A |
No. 1275 |
|
|||||
|
C00031985
|
Ophiohayatone B
/ (-)-Ophiohayatone B / Lucidin 3-O-primeveroside / (-)-Lucidin 3-O-beta-primeveroside |
CHEMBL521217
|
C064334
|
No. 1320 | No. 62 |
|
||
|
C00033228
|
Munjistin
|
No. 1811 | No. 62 |
|
||||
|
C00033342
|
Rubinaphthin B
/ (-)-Rubinaphthin B |
No. 2330 | No. 25 |
|
||||
|
C00033343
|
Rubinaphthin C
/ (-)-Rubinaphthin C |
No. 5674 |
|
|||||
|
C00033344
|
Rubinaphthin D
/ (-)-Rubinaphthin D |
No. 5674 |
|
Human Protein / Gene in interactions
66 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P06746 | DNA polymerase beta | Enzyme | C00001024 C00003672 C00023774 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001024 C00002682 C00003672 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000602 C00003672 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001024 C00002682 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00001024 C00023774 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000602 C00003672 | 1 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00001024 | 1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001024 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001024 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00001024 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00001024 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 | 0 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001024 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001024 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001024 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002682 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00001024 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002682 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00031526 | 0 / 0 |
| P27487 | Dipeptidyl peptidase 4 | S9B | C00001024 | 0 / 1 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00001024 | 1 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 | 0 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00001024 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001024 | 2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001024 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00001024 | 1 / 0 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023774 | 0 / 0 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00002682 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 | 1 / 1 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00032518 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001024 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001024 | 4 / 3 |
| P48147 | Prolyl endopeptidase | S9A | C00001024 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00032518 | 0 / 7 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001024 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001024 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00001024 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001024 | 1 / 2 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00001024 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00031526 | 2 / 1 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00001024 | 1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00001024 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00001024 | 1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00001024 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00001024 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00001024 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00001024 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00001024 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00001024 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00001024 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00001024 | 4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00001024 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00001024 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00001024 | 1 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00023774 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00023774 | 0 / 0 |
15 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001024
|
| 890 | CCNA2, CCN1, CCNA | cyclin A2 |
C00001024
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00001024
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001024
|
| 3280 | HES1, HES-1, HHL, HRY, bHLHb39 | hes family bHLH transcription factor 1 |
C00001024
|
| 23462 | HEY1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1 | hes-related family bHLH transcription factor with YRPW motif 1 |
C00001024
|
| 23493 | HEY2, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32 | hes-related family bHLH transcription factor with YRPW motif 2 |
C00001024
|
| 4851 | NOTCH1, TAN1, hN1 | notch 1 |
C00001024
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00001024
|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00023774
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002682
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002682
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002682
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002682
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002682
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (44)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P47869
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #162800 | Cyclic neutropenia |
P08246
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #607208 | Dravet syndrome |
P18507
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #143100 | Huntington disease; hd |
P42858
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
KEGG DISEASE (39)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P10415
(related)
|
| H00013 | Small cell lung cancer |
P10415
(related)
|
| H00018 | Gastric cancer |
P10415
(related)
|
| H00028 | Choriocarcinoma |
P10415
(related)
|
| H00030 | Cervical cancer |
P10415
(related)
|
| H00041 | Kaposi's sarcoma |
P10415
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00032 | Thyroid cancer |
P27487
(marker)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
7 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D002545 | Brain Ischemia |
C00001024
|
| D005355 | Fibrosis |
C00001024
|
| D007249 | Inflammation |
C00001024
|
| D008106 | Liver Cirrhosis, Experimental |
C00001024
|
| D008107 | Liver Diseases |
C00001024
|
| D011471 | Prostatic Neoplasms |
C00001024
|
| D015427 | Reperfusion Injury |
C00001024
|