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The Natural Products Journal

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ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

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Research Article

Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activity

Author(s): Mohammad Alhilal, Suzan Alhilal*, Sobhi Gomha* and Salama Ouf

Volume 12, Issue 5, 2022

Published on: 14 January, 2022

Article ID: e151021197237 Pages: 14

DOI: 10.2174/2210315511666211015085803

Price: $65

Abstract

Background: Adenocarpus complicatus L. is one of Adenocarpus genus, which has about 50 species, from Fabaceae (Papilionaceae) family. This plant is found in the Mediterranean basin as a southern west part of Europe and North Afric forestes.

Objective: Isolation of Isocarpine From Adenocarpus Complicatus as Anticandidal Agent.

Methods: A new piperidine alkaloid Isocarpine was isolated from the aerial parts of Adenocarpus complicatus L., which is gross in Syria. The structure of the new compound was determined by UV, IR, EI-Ms, 1H-NMR, 13C-NMR, DEPT-135, DQF-COSY and HMQC.

Results: The anticandidal activity of isocarpine was screened against 38 Candida strains and showed remarkable inhibitory effect compared with fluconazole as an antifungal reference drug.

Conclusion: Isocarpine is antifungal agent.

Keywords: Adenocarpus complicatus L, piperidine alkaloids, isocarpines, structure elucidation, fluconazole, antifungal activity.

Graphical Abstract

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