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2001, Memorias Do Instituto Oswaldo Cruz
The genus Polygonum (Polygonaceae), comprising about 300 species, is distributed worldwide, mostly in north temperate climates, is interesting from both biological and phytochemical perspectives. In this review, a contemporary summary of biological and pharmacological investigate on Polygonum species will be presented and critically evaluated. Significant findings in the treatment various diseases such as snake-bites, inflammatory, anticancer, antibacterial, antivirus, antiseptic, antifungal, diabetic, hypertension, hyperlipemia, jaundice, hemorrhage, cough, fever, ulcers, skin affections, anemia, diarrhea and various urologic disorders, have been presented in ethnobotanical reports and recent studies were performed on ethanol extracts for certain Polygonum species. Polygonum, the most important constituent isolated is known to possess anticancer activity. Very few additional data are available on the biological activities and cytotoxicity of pure compounds from Polygonum. Twenty-ni...
Journal of Pharmacy and Pharmacology
Therapeutically important bioactive compounds of the genus Polygonum L. and their possible interventions in clinical medicineObjectives Increasing literature data have suggested that the genus Polygonum L. possesses pharmacologically important plant secondary metabolites. These bioactive compounds are implicated as effective agents in preclinical and clinical practice due to their pharmacological effects such as anti-inflammatory, anticancer, antidiabetic, antiaging, neuroprotective or immunomodulatory properties among many others. However, elaborate pharmacological and clinical data concerning the bioavailability, tissue distribution pattern, dosage and pharmacokinetic profiles of these compounds are still scanty. Key findings The major bioactive compounds implicated in the therapeutic effects of Polygonum genus include phenolic and flavonoid compounds, anthraquinones and stilbenes, such as quercetin, resveratrol, polydatin and others, and could serve as potential drug leads or as adjuvant agents. Data from in-silico network pharmacology and computational molecular docking studies are also highly helpful...
Revista Boliviana de Quimica
DETERMINATION OF AN ACTIVE PRINCIPLE OF POLYGONUM PUNCTATUM ELLIOT; FULL NMR SPECTRA OF STIGMAST-5-EN-3-OL (500/125 MHz)2017 •
The aim of this article is to provide full NMR spectra (1H 500 MHz, 13C 125.8 MHz) of stigmast-5-en-3-ol (1), whose other common names are: -sitosterol, -sitosterin, 22,23-dihydrostigmasterol, and IUPAC name: 17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1-cyclopenta[a]phenanthren-3-ol., and IUPAC name: The spectra set includes HMBC, HSQC and COSY studies. ROESY or NOESY studies were excluded. Compound 1 is found to be the major component of the alcoholic extract of roots of Polygonum punctatum (Polygonaceae), a macrophyte native species of Paraguay with varied therapeutic applications like anti-inflammatory among others. Compound 1 was extracted by maceration in EtOH 96° and it was isolated by using chromatographic techniques. A bibliographic research allowed to establish a correlation between traditional medicine information of anti-inflammatory property of P. punctatum and the isolated compound 1 for which a series of reports about its pharmacological properties permitted to affirm that 1, being the major secondary metabolite in the alcoholic extract of roots, is one of the active principles of the plant, namely the anti-inflammatory principle. The spectroscopic work and the structural elucidation permitted the identification of compound 1 as -sitosterol. The bibliographic research allowed to label -sitosterol (1) as a new compound in the species P. punctatum for which only polygodial, a potent antifungal sesquiterpene, was previously described. With the present reporting of compound 1 in P. punctatum, the total number of secondary metabolites and active principles thus far described in the species reaches the cipher of two (according to the newest bibliographic review on the chemical content of the Polygonum genus, 2014).
Phytomedicine
Antimicrobial, antiviral and cytotoxic activity of extracts and constituents from Polygonum spectabile Mart2010 •
Stamford Journal of Pharmaceutical Sciences
Chemical and Biological Investigation of Leaves of Polygonum plebejum2010 •
The cytotoxic and antimicrobial activity of methanol crude extract and column fractions of the extract of theleaves of P. plebejum were examined by brine shrimp lethality bioassay and disc diffusion methodrespectively. The extracts showed significant cytotoxic as well as antimicrobial activities. Silica gel columnchromatography of methanol extract of P. plebejum afforded a steroid. The structure was elucidated on thebasis of spectral analysis, including 1H NMR and 13C NMR and also by comparing with data in the literature. Key words: Polygonum plebejum; Polygonaceae; Stigmasterol; Cytotoxicity.DOI: 10.3329/sjps.v2i2.5826Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 66-71
European Journal of Medicinal Plants
Evaluation of Multiple Functions of Polygonum Genus Compounds2015 •
2019 •
This work deals with the development of a procedure for the isolation of a complex of biologically active substances from the aerial parts of some plants of Polygonum L. grown up in Kazakhstan and the determination of a possibility of their application to officinal medicine. The effect of various factors (the temperature, the extraction time, the raw material: solvent ratio) on the chemical composition of the extracts of a high yield of biologically active substances from Polygonum minus, P. aviculare, P. hydropiper is studied.
Polygonatum verticillatum (Linn.) All. syn. Convallaria verticillata Linn. is a valuable medicinal plant, distributed in the temperate Himalaya at the elevations 2 400 to 2 800 m. It is a perennial rhizomatous herb and contains various pharmacologically important secondary metabolites among which the most important are α-bulnesene, linalyl acetate, eicosadienoic, pentacosane, piperitone, docasane, diosgenin, santonin and calarene. It also possesses antimalarial, antipyretic, anti-inflammatory, anticonvulsant, lipoxygenase, urease inhibition, diuretic, tracheorelaxant, antidiarrheal, antispasmodic, antinociceptive, antifungal, antibacterial and bronchodilator activities. The plant also got importance in traditional systems of medicine due to its broad therapeutic potential especially of its rhizome. But in the past few years, over exploitation of plant parts caused the decline in the frequency of this species due to which it became threatened, endangered and vulnerable in different parts of the world. So efforts are being made in certain regions of the world for both ex-situ and in-situ conservation. This paper briefly reviewed the botanical, traditional, phytochemical, pharmacological and conservation related aspects of this plant.
Traditional system of Medicine is the most widely practiced system of medicine, which incorporates natural sources like entire plants or their parts. The therapeutic of drugs used in various systems greatly depends on the use of proper and genuine raw materials. Because of these, assurance of safety, quality, and of medicinal plants and herbal products has now become a key issue. Pharmacognostic studies play a vital role in assessing the quality, purity and identification of a plant drug. The misuse of herbal medicine or natural product starts with wrong identification which can be solved by pharmacognostic studies of medicinal plants. According to WHO, the pharmacognostic evaluation of a medicinal plant is the first step to be carried out to establish its identity and purity? The Physicochemical screening are also important to cheek if the drug is adulterant or not. Phytochemical screening is also important to find out the active chemical constituents like Alkaloid, glycoside, tannin, protein etc present or not in the extracts. Hence the present study deals with the details pharmacognostical and preliminary phytochemical studies of leaves of Polygonum muricatum commonly known as Jabuit from Polygonaceae family.
2000 •
Optics Express
High-efficiency second-harmonic generation in doubly-resonant χ^(2) microring resonators2012 •
European Journal of Pharmacology
Interaction studies of 5-HT1A receptor antagonists and selective 5-HT reuptake inhibitors in isolated aggressive mice2008 •
2016 •
Revista Brasileira de Ciências do Esporte
Antropometria e somatotipo: fatores determinantes na seleção de atletas no voleibol brasileiro2011 •
Journal of the Japanese Forest Society
Effect of Planting Season on Survival Rate, Growth and Ecophysiological Properties of Container Seedlings of Japanese Larch (Larix kaempferi)2016 •
International Journal of Environmental Research and Public Health
Assessment of Safe Listening Intentional Behavior Toward Personal Listening Devices in Young Adults2019 •
2013 •
The Breast Journal
Breast Cancer Burden in Maiduguri, North Eastern Nigeria2008 •
Magallania (Punta Arenas)
Historia Reproductora y Fecundidad De Las Mujeres Chilenas De Tierra Del FuegoEuropean Journal of Operational Research
Elicitation of multiattribute value functions through high dimensional model representations: Monotonicity and interactions2015 •
Revista Española de Discapacidad
Un debate entre lo personal y lo público: la interdicción como pretexto2018 •
2017 •
Journal of Medical Ethics
Strange Bedfellows. How Medical Jurisprudence Has Influenced Medical Ethics and Medical Practice: B A Rich, Kluwer Academic/Plenum Publishers, 2001, $US55, pp 196. ISBN: 03064666512003 •
Liquid Nationalism and State Partitions in Europe
Introduction: Geopolitical liquidities and nationalist trajectories: fluid boundaries and state reshaping in nineteenth-century EuropeMetabolic Syndrome and Related Disorders
Nasal and Parotid Blood Pool Activity Is Significantly Correlated with Metabolic Syndrome Components and Sleep ApneaArchivum Immunologiae et Therapiae Experimentalis
The Positive Impact of Donor Bone Marrow Cells Transplantation into Immunoprivileged Compartments on the Survival of Vascularized Skin Allografts2021 •
Вестник Концерна ВКО «Алмаз – Антей»
Reducing deformations in thin-sheet high-strength steel structures based on CAE-analysis of welded joints2018 •