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2020
Methods: Phytochemical screening was performed using the drop Test. For hepatoxicity study, albino rats were randomized into 5 groups of 6 each. Healthy group: without hepatoxicity; Control group: hepatotoxicity; Curative group: hepatotoxicity plus fluid extract of N. albopunctatissimum Lellinger; Standard group: hepatotoxicity plus silymarin; Preventive group: Fluid extract of N. albopunctatissimum Lellinger for one week, then hepatotoxicity. Hepatotoxicity was induced with 56% (w / v) ethanol at doses of 7.6 mL / kg p.c every 12 hours for 7 days. Glutamic pyruvic transaminase (GPT) values were determined at baseline, 7 days after induction and 14 days after. A histopathological study of the livers was performed.
Alysicarpus vaginalis (L.) DC commonly known as Alyce clover, belongs to the botanical family Fabaceae. It is widely distributed in India, Pakistan, Sri Lanka , Africa and Australia. In India it is traditionally used by the tribals for diuretics, leprosy, pulmonary troubles and back pain. The present study aimed to evaluate the hepatoprotective activity of ethanol extract of A. vaginalis aerial parts in nitrobenzene (NB) induced hepatic injury in Wistar rats. Liver injury was induced in rats by single oral administration of of NB (50 mg/kg bw). One days after NB induction, the rats were treated with ethanolic extract of A. vaginalis orally at the doses of 200 mg/kg bw daily for 30 days. Silymarin (25 mg/kg bw orally) was used as reference drug. After 30 days serum biochemical parameters, antioxidant enzyme status and histopathological parameters were analyzed. The results indicated that the ethanol extract of A. vaginalis the doses of 200 mg/kg orally significantly (P< 0.05) and dose-dependently reduced and normalized the serum marker enzymes, and increased the antioxidant enzyme status as compared to that of NB control group. Further more it was confirmed by histopathological studies. This study concludes that A. vaginalis demonstrated promising hepatoprotectivity agent in NB induced hepatic damaged rats.
BioMed Research International
Effect ofAlocasia indicaTuber Extract on Reducing Hepatotoxicity and Liver Apoptosis in Alcohol Intoxicated Rats2014 •
The possible protective role of ethanolic extract ofA. indicatuber (EEAIT) in hepatotoxicity and apoptosis of liver caused by alcohol in rats was investigated. Treatment of rats with alcohol (3 g ethanol per kg body weight per day for 15 days intraperitoneally) produced marked elevation of liver biomarkers such as serum alanine aminotransferase (ALT), aspartate aminotransferase (AST),γ-glutamyl transpeptidase (γ-GT), and total bilirubin levels which were reduced by EEAIT in a dose-dependent manner. Furthermore, EEAIT improved antioxidant status (MDA, NO, and GSH) and preserved hepatic cell architecture. Simultaneous supplementation with EEAIT significantly restored hepatic catalase (CAT) and superoxide dismutase (SOD) activity levels towards normal. The studies with biochemical markers were strongly supported by the histopathological evaluation of the liver tissue. EEAIT also attenuated apoptosis and necrosis features of liver cell found in immunohistochemical evaluation. HPLC analy...
International Journal of Pharmacy and Pharmaceutical Sciences
THERAPEUTIC EFFICACY OF ISOLATED STIGMA-5,22 DIEN-3-O-B-D-GLUCOPYRANOSIDE AND ETHANOLIC ROOT EXTRACT OF OPERCULINA TURPETHUM AGAINST N- NITROSODIMETHYLAMINE INDUCED HEPATOPATHY IN THE LIVER OF MICE: ULTRASTRUCTURAL AND HISTOLOGICAL EVIDENCES Original Article2014 •
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
Hepatoprotective Activity of BV-7310, a Proprietary Herbal Formulation of Phyllanthus niruri, Tephrosia purpurea, Boerhavia diffusa, and Andrographis paniculata, in Alcohol-Induced Hep G2 Cells and Alcohol plus a Haloalkane, CCl4, Induced Liver Damage in Rats2020 •
Excessive alcohol consumption is a worldwide threat with severe morbidity and mortality. Other than abstinence, there is still no FDA-approved drug for alcoholic liver disease (ALD). Liver is the primary site of ethanol metabolism and hence gets the most damage from excessive drinking. It triggers multiple signalling events including inflammation, leading to an array of hepatic lesions like steatosis, hepatitis, fibrosis, and cirrhosis. Similarly, when medications or xenobiotic compounds are ingested orally, the liver gets the highest exposure of those metabolites, which in turn can cause severe liver toxicity. BV-7310 is a standardized mixture of four Ayurvedic plants, namely, Phyllanthus niruri, Tephrosia purpurea, Boerhavia diffusa, and Andrographis paniculata. In different systems of traditional medicine, each of these plants has been known to have use in gastrointestinal disorders. We wanted to assess the combined effect of these plant extracts on alcohol-induced liver damage. First, we investigated the hepatoprotective activity of BV-7310 against alcohol-induced toxicity in human liver HepG2 cells. Ethanol treatment (120 mM for 48 hours) significantly showed toxicity (around 42%) in these cells, and coincubation with BV-7310 prevented ethanol-induced cell death in a dose-dependent manner. Interestingly, the formulation BV-7310 showed synergistic activity than any individual extract tested in this assay. BV-7310 also showed potent antioxidant activity in 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay. Next, we induced hepatitis in Sprague-Dawley (SD) rats using repeated alcohol (40%) dosing, and carbon tetrachloride (CCl 4) 24 hours before termination. Both oral doses of BV-7310 (250 and 500 mg/kg body weight) protected the alcohol-induced body weight loss and significantly improved the elevated levels of liver enzymes compared to the vehicle treated group. us, BV-7310 prevents alcohol-induced toxicity in both in-vitro and in-vivo models and could be beneficial for the treatment of ALD or other conditions, which may cause liver toxicity.
Background: Alnus nitida (Spach) Endl. is traditionally used for inflammatory disorders. Diarylheptanoids constituents having diverse therapeutically importance including hepato-protective was reported in A. nitida. The aim of this study was to explore the antioxidant and hepato-protective profile of A. nitida stem bark's crude methanol extract (ANM). Methods: Crude methanol extract of A. nitida stem bark and its derived fractions were assessed for phytochemical classes and in vitro antioxidant profiling by multidimensional assays. Hepato-protective assessment of ANM was investigated on rats, which were made hepatotoxic using carbon tetrachloride (CCl 4). Additionally HPLC-DAD analysis of ANM, and its derived ethyl acetate and aqueous fraction was carried out to determine the presence of active constituents. Results: Qualitative analysis of crude extract-and its fractions depicted the presence of terpenoids, saponins, coumarins, phenols and flavonoids. Maximum quantity of total phenolic content (TPC) and total flavonoid content (TFC) was recorded in ANM and its derived fractions; n-hexane (ANH), chloroform (ANC), ethyl acetate (ANE) and the residual aqueous (ANA). ANM exhibited the best total antioxidant capacity, total reducing power, and scavenging of DPPH and OH radicals. ANE and ANA exhibited strong scavenging potential for iron chelation, nitric oxide and β-carotene bleaching assay. ANM treatment converse the activities of serum-marker enzymes and lipid profile, altered by CCl 4 treatment in rat. CCl 4 induced hepatic-cirrhosis in rat resulted in decrease of antioxidant enzyme activities such as catalase, peroxidase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase-which were restored towards the normal level with ANM. Similarly diminished level of reduced glutathione while enhanced level of lipid peroxides, hydrogen peroxide and nitrite in liver of cirrhotic rats was normalized by treatment of ANM. The histopathological studies of liver tissues also represented that ANM possessed the hepato-protective activity. HPLC-DAD analysis against eight known standards confirmed the presence of gallic acid, catechin and rutin in ANM and in ANA while in ANE gallic acid was only detected. Conclusion: Based on the results of antioxidants, restoration of various antioxidant enzymes and histopathological studies, the recent study concludes that antioxidant potential of A. nitida bark might protect the liver damages.
Ethiopian Pharmaceutical Journal
Evaluation of Hepatoprotective Activities of Satureja punctata Benth Briq and Solanecio angulatus Vahl Jeffrey in Ferric Nitrillotriacetate Induced Hepatotoxicity in Rats2012 •
Hepatoprotective activity of Nerium indicum leaves extracts were investigated in CCl4 induced hepatotoxic albino rats. A comparison was made between the action of leaves extracts of Nerium indicum and a known hepatoprotective drug silymarin. Alteration in the levels of biochemical markers of hepatic damage like SGPT, SGOT, ALP, bilirubin, were tested in both treated and untreated groups. Carbon tetra chloride (2 ml/kg) increased the SGPT, SGOT, ALP and bilirubin level in rats. Results showed that treatment with ethanolic extract of Nerium indicum restored the altered levels of biochemical markers to the near normal levels in the dose dependent manner.
European Journal of Medicinal Plants
Hepatoprotective Effect of Aqueous Extract of Lippia multiflora Leaves against Ethanol-induced Toxicity in Wistar Rats2015 •
Jurnal Kedokteran Hewan - Indonesian Journal of Veterinary Sciences
HEPATOPROTECTIVE ACIVITY OF THE ETHANOLIC EXTRACT OF DOG FRUIT RIND (Pithecellobium lobatum Benth.)The present study was conducted to investigate the hepatoprotective activity of ethanolic extract of dog fruit rind (Pithecellobium lobatum benth.) against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Male Wistar albino rats were randomly divided into four groups and administered orally with 50 mg/200 g body weight of dog fruit rind extract (K1), 100 mg/200 g body weight (K2) of dog fruit rind extract, 5 mg/200 g body weight of silymarin (K3/positive control), and 0.4 mL/200 g body weight of distilled water (K4/negative control), for seven days The levels of alanine transaminase (ALT) of each K1; K2; K3; and K4 were 143.40±83.75 U/L, 94.80±93.77 U/L, 130.20±58.54 U/L and 147.25±107.97 U/L, respectively, while the aspartate transaminase (AST) levels were 304.20±128.67 U/L; 213.20±88.93 U/L; 333.00±128.31 U/L; and 239.25 ± 94.90 U/L, respectively (P>0.05). Group K2 showed better histological pattern than other groups with 60% of mild and 40% of moderate liver damage....
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