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2004
Natural products have gained popularity worldwide for promoting healthcare, as well as disease prevention. Medical use of alkaloid-containing plants has a long history and many alkaloids are still used in medicine nowaday. Alkaloids possessed wide range of pharmacological and therapeutic effects. The current manuscript discussed the plant contents of alkaloids for medical, pharmaceutical, synthetic, and many other useful properties.
Turk. J. Vet. Anim …
Toxicity of Heliotropium dolosum, Heliotropium circinatum, and Senecio vernalis in parental quail and their progeny, with residue evaluation of eggs2008 •
Journal of Agricultural and Food Chemistry
Heliotropium europaeum Poisoning in Cattle and Analysis of Its Pyrrolizidine Alkaloid Profile2015 •
1991 •
Investigation of the pyrrolizidine alkaloids of Heliotropium arbainense resulted in the isolation and identification of heliotrine, europine and 7-angelylheliotrine. From H. ovalifolium three alkaloids were isolated: supinine, 7-angelylheliotridine and an alkaloid which was shown to be of the heliotridine monoester type with a dehydrated viridifloric acid.
Herba Polonica
Pyrrolizidine alkaloids - chemistry, biosynthesis, pathway, toxicity, safety and perspectives of medicinal usage2009 •
S u m m a r y Pyrrolizidine alkaloids (PAs) are the class of secondary metabolites that evolved as a powerful tool in the plant defensive interactions against herbivores. The occurrence of PAs in the plant world is scattered in several unrelated botanic families with special abundance in Asteraceae, Boraginaceae and Fabaceae. Homospermidine synthase (HSS) was recognized as a key enzyme that catalyzes homospermidine formation from polyamines. The studies of HSS kinetic and gene sequence revealed that it is of polyphyletic origin and raised as a result of deoxyhypusine synthase (DHS) gene duplication. The ability of PAs production occurred independently at least four times in course of plant evolution. The PAs biosynthesis is tightly correlated with growth phase and biomass production. It is supposed that PAs biosynthesis is individually regulated in different lineages of plants. The PAs with a 1,2 unsaturated necine skeleton show toxic activity (hepatoxicity, carcinogenicity, genotox...
Pyrrolizidine alkaloids (PAs) are a diverse group of plant secondary metabolites with known varied toxicity. Consumption of 1,2-unsaturated PAs has been linked to acute and chronic liver damage, carcinogenicity and death, in livestock and humans, making their presence in food of concern to food regulators in Australia and internationally. In this survey, honey samples sourced from markets and shops in Queensland (Australia), were analysed by high-resolution Orbitrap UHPLC-MS/MS for 30 common PAs. Relationships between the occurrence of pyrrolizidine alkaloids and the botanical origin of the honey are essential as pyrrolizidine alkaloid contamination at up to 3300 ng/g were detected. In this study, the predominant alkaloids detected were isomeric PAs, lycopsamine, indicine and intermedine, exhibiting identical MS/MS spectra, along with lesser amounts of each of their N-oxides. Crucially, chromatographic UHPLC conditions were optimised by operation at low temperature (5 °C) to resolve...
2018 •
Ethnomedicinal practices used in better health treatment system from ancient time. Phytomedicines are now an essential area of better treatment and high prospects in many nations. It is less expensive as well as has better cultural and societal recognition, has better feasibility with the human physiological system and has decidedly fewer side effects. Heliotropium indicum Linn. (Family- Boraginaceae) an annual herbaceous medicinal weed and it is commonly known as Indian heliotrope. It is not only a common weed but also it is an important medicinal herb, too. These medicinal herbs are found in tropical and temperate parts of the world along with India, Bangladesh, and some other African countries. Extensive literature studies suggested that the various parts of the plant are reported to possess anti-microbial, anti-tumor, anti-tuberculosis, antiplasmodial, anti-cataract, anti-fertility, wound healing, anti-inflammatory, antinociceptive, analgesic and histo-gastro protective properti...
Introduction: A huge number of plants have remedial and therapeutic prospects throughout the world and are used in the treatment of diverse diseases. Heliotropium is a large genus of family Boraginaceae which widely distributed in tropical and temperate regions of hemispheres. The purpose of this review is to recapitulate the phytochemistry and pharmacological activities of the Heliotropium species to unveil future research prospects. Methods: Published data in this review were all gathered from the online bibliographical databases: PubMed, Elsevier, Scopus, Google Scholar and Web of Science. Results: The plants of the Heliotropium genus in the history of traditional drugs provide remedies for gout, inflammation , skin disorders, menstrual dysfunction, rheumatism, and noxious bites. The active biochemical constituents extracted from the Heliotropium species comprise pyrrolizidine alkaloids, flavonoids, and terpenoids. Significant biological activities viz. antimicrobial, antiviral, antitumor, anti-inflammatory, cytotoxicity, phytotox-icity, and wound healing were revealed by an enormous number of extracts and biochemically active constituents of various species of the Heliotropium genus. Conclusion: Phytomedicines are now an important and beneficial zone of the recommended treatment and have high potentials in many countries. Although this clear evidence that plants of the Heliotropium genus have several medicinal importance in the treatment of diverse diseases. The medicinal use of these plants as phyto-pharmaceuticals would depend on the production of the required systematic procedures necessary to standardize the various bioactive secondary metabolites in such herbal formulations. Therefore, we conclude that in the coming period, plants of the Heliotropium genus would become an acceptable source of indigenous medicines.
2009 •
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
Transfer of pyrrolizidine alkaloids from various herbs to eggs and meat in laying hens2016 •
Journal of Medicinal Plants Studies
A review on some endemic and near endemic plants of Toor Al-Baha District, Lahej Governorate, Yemen2020 •
International Journal of Molecular Sciences
Metabolic Toxification of 1,2-Unsaturated Pyrrolizidine Alkaloids Causes Human Hepatic Sinusoidal Obstruction Syndrome: The UpdateEvidence-based Complementary and Alternative Medicine : eCAM
Heliotropium indicum L.: From Farm to a Source of Bioactive Compounds with Therapeutic Activity2021 •
2011 •
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques
Hepatotoxicity of Pyrrolizidine Alkaloids2015 •
Journal of Chemical Ecology
Acquired and Partially De Novo Synthesized Pyrrolizidine Alkaloids in Two Polyphagous Arctiids and the Alkaloid Profiles of Their Larval Food-Plants2000 •
Journal of Agricultural and Food Chemistry
Development of a class-specific competitive enzyme-linked immunosorbent assay for the detection of pyrrolizidine alkaloids in vitro1992 •
Ankara Universitesi Eczacilik Fakultesi Dergisi
Antimicrobial Activity of Some Thiadiazolyl- and Triazolylbenzimidazoles : Bazi Ti̇yadazoul- Ve Tri̇azoli̇lbenzi̇mi̇dazol Türevleri̇ni̇n Anti̇mi̇krobi̇yal Akti̇vi̇teleri̇2004 •
uvt.ulakbim.gov.tr
Antimicrobial Activity of Some Thiadiazolyl-And TriazolylbenzimidazolesJournal of Toxicology
An Outbreak of Hepatic Veno-Occlusive Disease in Western Afghanistan Associated with Exposure to Wheat Flour Contaminated with Pyrrolizidine Alkaloids2010 •
2015 •
1997 •
2020 •
Phytochemistry
Pyrrolizidine Alkaloids of the Endemic Mexican Genus Pittocaulon and Assignment of Stereoisomeric 1, 2-Saturated Necine Bases2008 •
2014 •
Journal of Toxicology and Environmental Health, Part B
Metabolism, Genotoxicity, annd Carcinogenicity of Comfrey2010 •
Insect Biochemistry and Molecular Biology
Acquisition, transformation and maintenance of plant pyrrolizidine alkaloids by the polyphagous arctiid Grammia geneura2005 •
Pharmaceutical Biology
The Evaluation of Plants from Turkey for in Vitro . Antimycobacterial Activity2005 •
Biochemical Systematics and Ecology
Pyrrolizidine alkaloids from Canarian endemic plants and their biological effects2008 •
Journal of Ethnopharmacology
The effect of Senecio latifolius a plant used as a South African traditional medicine, on a human hepatoma cell line2001 •
Turkish Journal of Biology
Characterisation and antimicrobial activity of Sophora alopecuroides L. var. alopecuroides alkaloid extracts2011 •
Journal of Comparative Physiology ? A
A pheromone precursor and its uptake in maleDanaus butterflies1975 •
2014 •
Mutation Research/Genetic Toxicology
Genotoxic action of an aqueous extract of Heliotropium curassavicum var. argentinum1992 •
2004 •
2010 •
2000 •