Eleven new iridoids, brachybones A–K (1–11), were isolated from the twigs of Viburnum brachybotryum. Their structures including absolute configurations were determined by spectroscopic data analysis and from the electronic circular dichroism (ECD) spectra. All of the compounds 1–11 possess one or two acetoxysenecioate substituents. Furthermore, compounds 5–7 and 11 feature a Cl atom in the molecule, while compounds 9–11 exhibit a cagelike rigid skeleton through an unusual oxo bridge from C-3 to C-8 or C-10. The isolates were evaluated for cytotoxic activity against the HCT-116, A549, and Hela cell lines, and the results showed compounds 10 and 11 to be active against HCT-116 cells.

中文翻译：

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Viburnum brachybotryum 的环烯醚萜成分

11个新环烯醚萜，brachybones A-K（1 - 11），购自的细枝分离荚brachybotryum。它们的结构包括绝对构型是通过光谱数据分析和电子圆二色性 (ECD) 光谱确定的。所有的化合物的1 - 11具有一个或两个取代基acetoxysenecioate。此外，化合物5 – 7和11在分子中具有 Cl 原子，而化合物9 – 11通过从 C-3 到 C-8 或 C-10 的不寻常的氧桥展示笼状刚性骨架。评估了分离株对 HCT-116、A549 和 Hela 细胞系的细胞毒活性，结果显示化合物10和11对 HCT-116 细胞具有活性。