Skip to main content
  • 795 Accesses

Abstract

Nigella sativa (also known as black seed) has recently become popular for its many effects and is among the most demanded herbs. Nigella sativa seeds, which are among the herbs used for medicinal purposes, are used in traditional medicine in Asia, Far East, and Middle East countries for purposes such as headache, abdominal pain, diarrhoea, asthma, cough, and rheumatism. The anti-inflammatory, analgesic, anticancer, antitumoural, antibacterial, antifungal, antioxidant, immunological, antidiabetic, antihistaminic, antisestodal, and hepatoprotective effects of the plant’s seed have been determined through in vitro and in vivo biological activity studies conducted for about 30 years. Various pharmacological effects of the plant, which is generally used as a spice to decorate and flavour donuts in our country, have also been discovered in recent years, supported by experimental data. In this section, studies on the botanical characteristics, chemical content, and biological activity of N. sativa have been compiled.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abdel-Fattah AM, Matsumoto K, Watanabe H. Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice. Eur J Pharmacol. 2000;400:89–97.

    Article  CAS  PubMed  Google Scholar 

  • Aboul Ela MA, el-Shaer NS, Ghanem NB. Antimicrobial evaluation and chromatographic analysis of some essential and fixed oils. Pharmazie. 1996;51:993–4.

    CAS  PubMed  Google Scholar 

  • Aggarwal R, Kharya M, Shrivastava R. Antimicrobial and anthelmintic activities of the essential oil of Nigella sativa Linn. Indian J Exp Biol. 1979;17:1264–5.

    Google Scholar 

  • Agrawala I, Achar M, Tamankar B. Galactagogue action of Nigella sativa. Indian J Med Sci. 1971;25:535–7.

    CAS  PubMed  Google Scholar 

  • Ahmad MF, Ahmad FA, Ashraf SA, et al. An updated knowledge of Black seed (Nigella sativa Linn.): review of phytochemical constituents and pharmacological properties. J Herb Med. 2021;25:100404.

    Article  PubMed  Google Scholar 

  • Akbulut S, Bayramoglu MM. The trade and use of some medical and aromatic herbs in Turkey. Ethno-Medicine. 2013;7:67–77.

    Article  Google Scholar 

  • Akhtar M, Aslam M. Anticestodal principles of Nigella sativa Linn. (Kolanji) seeds. Pak J Pharmacol. 1997;14:7–14.

    CAS  Google Scholar 

  • Akhtar A, Ahmad K, Gilani S, et al. Antiulcer effect of aqueous extracts of Nigella sativa and Pongamia pinnata in rats. Fitoterapia. 1996;67:195–9.

    Google Scholar 

  • Al-Gaby AM. Amino acid composition and biological effects of supplementing broad bean and corn proteins with Nigella sativa (black cumin) cake protein. Nahrung. 1998;42:290–4.

    Article  CAS  PubMed  Google Scholar 

  • Al-Hader A, Aqel M, Hasan Z. Hypoglycemic effect of the volatil oil of Nigella sativa seeds. Int J Pharmacol. 1993;31:96–100.

    Google Scholar 

  • Ali B, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res. 2002;15:59–69.

    Google Scholar 

  • Ali Z, Ferreira D, Carvalho P, et al. Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa. J Nat Prod. 2008;71:1111–2.

    Article  CAS  PubMed  Google Scholar 

  • Ali SA, Parveen N, Ali AS. Links between the Prophet Muhammad (PBUH) recommended foods and disease management: a review in the light of modern superfoods. Int J Health Sci (Qassim). 2018;12:61–9.

    Google Scholar 

  • Al-Jassir MS. Chemical composition and microflora of black cumin (Nigella sativa L) seeds growing in Saudi Arabia. Food Chem. 1992;45:239–42.

    Article  CAS  Google Scholar 

  • Al-Naggar TB, Gómez-Serranillos MP, Carretero ME, et al. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol. 2003;88:63–8.

    Article  CAS  PubMed  Google Scholar 

  • Atta M, Imaizumi K. Antioxidant activity of Nigella sativa L. seeds extracts. J Jap Oil Chem Soc. 1998;47:475–80.

    Article  CAS  Google Scholar 

  • Bellakhdar J, Claisse R, Fleurentin J, et al. Repertory of standard herbal drugs in the Moroccan pharmacopoea. J Ethnopharmacol. 1991;35:123–43.

    Article  CAS  PubMed  Google Scholar 

  • Benkaci-Ali F, Baaliouamer A, Meklati BY. Kinetic study of microwave extraction of essential oil of Nigella sativa L. seeds. Chromatographia. 2006;64:227–31.

    Article  CAS  Google Scholar 

  • Botnick I, Xue W, Bar E. Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses. Molecules. 2012;17:10159–77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bourgou S, Ksouri R, Bellila A, et al. Phenolic composition and biological activities of Tunisian Nigella sativa L. shoots and roots. C R Biol. 2008;331:48–55.

    Article  CAS  PubMed  Google Scholar 

  • Burits M, Bucar F. Antioxidant activity of Nigella sativa L. essential oil. Phytother Res. 2000;14:323–8.

    Article  CAS  PubMed  Google Scholar 

  • Butt UJ, Shah SAA, Ahmed T, et al. Protective effects of Nigella sativa L. seed extract on lead induced neurotoxicity during development and early life in mouse models. Toxicol Res (Camb). 2017;7:32–40.

    Article  Google Scholar 

  • Dadandi MY, Kökdil G, İlçim A, et al. Seed macro and micro morphology of the selected Nigella (Ranunculaceae) taxa from Turkey and their systematic significance. Biologia. 2009;64:261–70.

    Article  Google Scholar 

  • Datta AK, Saha A, Bhattacharya A, et al. Black cumin (Nigella sativa L.)–a review. JPDS. 2012;4:1–43.

    Google Scholar 

  • Davis PH. Flora of Turkey and the East Aegean Islands, vol. 1. Edinburgh: Edinburgh University Press; 1965. p. 95–108.

    Google Scholar 

  • Davis PH. Flora of Turkey and the East Aegean Islands, vol. 10. Edinburgh: Edinburgh University Press; 1988. p. 13–4.

    Google Scholar 

  • Dönmez AA, Mutlu B. A new species of Nigella (Ranunculaceae) from Turkey. Bot J Linn Soc. 2004;146:251–5.

    Article  Google Scholar 

  • El-Dakhakhny M, Madi NJ, Lembert N, et al. Ammon HP. Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. J Ethnopharmacol. 2002;81:161–4.

    Article  CAS  PubMed  Google Scholar 

  • El-Kadi A, Kandil O. The black seed (Nigella sativa) and immunity: its effect on human T celle subset. Fed Proc. 1987;46:1222.

    Google Scholar 

  • El-Naggar T, Gómez-Serranillos MP, Palomino OM, et al. Nigella sativa L. seed extract modulates the neurotransmitter amino acids release in cultured neurons in vitro. J Biomed Biotechnol. 2010;2010:398312.

    Article  PubMed  PubMed Central  Google Scholar 

  • El-Tahir K, Ashour M, Al-Harbi M. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol. 1993;24:1123–31.

    Article  CAS  PubMed  Google Scholar 

  • Evans WC. Trease and Evans pharmacognosy. 15th ed. Edinburgh: W B Saunders; 2002. p. 23.

    Google Scholar 

  • Houghton PJ, Zarka R, de las Heras B, et al. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med. 1995;61:33–6.

    Article  CAS  PubMed  Google Scholar 

  • Hussain DA, Hussain MM. Nigella sativa (black seed) is an effective herbal remedy for every disease except death-a Prophetic statement which modern scientists confirm unanimously: a review. Adv Med Plant Res. 2016;4:27–57.

    Google Scholar 

  • Islam SN, Begum P, Ahsan T, et al. Immunosuppressive and cytotoxic properties of Nigella sativa. Phytother Res. 2004;18:395–8.

    Article  CAS  PubMed  Google Scholar 

  • Jain RK. Molecular regulation of vessel maturation. Nat Med. 2003;9:685–93.

    Article  CAS  PubMed  Google Scholar 

  • Kabli S. Effect of some bioagents on growth and toxin production of Aspergillus flavus Link. J Food Agric Environ. 2009;7:219–23.

    CAS  Google Scholar 

  • Kanter M, Coskun O, Uysal H. The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage. Arch Toxicol. 2006;80:217–24.

    Article  CAS  PubMed  Google Scholar 

  • Keshri G, Singh MM, Lakshmi V. Post-coital contraceptive efficacy of the seeds of Nigella sativa in rats. Indian J Physiol Pharmacol. 1995;39:59–62.

    CAS  PubMed  Google Scholar 

  • Khan MA. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammopharmacology. 1999;7:15–35.

    Article  CAS  PubMed  Google Scholar 

  • Kumara SS, Huat BT. Extraction, isolation and characterisation of antitumor principle, alpha-hederin, from the seeds of Nigella sativa. Planta Med. 2001;67:29–32.

    Article  CAS  PubMed  Google Scholar 

  • Mahfouz M, Abdel Maguid R, El-Dakhakhny M. Effectiveness of nigellone in asthma in adults. Alex J Med. 1960;6:543–7.

    Google Scholar 

  • Merfort I, Wray V, Barakat HH, et al. Flavonol triglycosides from seeds of Nigella sativa. Phytochemistry. 1997;46:359–63.

    Article  CAS  Google Scholar 

  • Mukhallad A, Mohamad A, Hatham D. Effects of black seeds (Nigella sativa) on spermatogenesis and fertility of male albino rats. Res J Med Sci. 2009;4:386–90.

    Google Scholar 

  • Nair M, Vasudevan P, Venkitanarayanan K. Antibacterial effect of black seed oil on Listeria monocytogenes. Food Control. 2005;16:395–8.

    Article  CAS  Google Scholar 

  • Nergiz C, Otles S. Some characteristics of Nigella sativa L. seed cultivated in Egypt and its lipid profile. Food Chem. 2003;83:63–8.

    Article  Google Scholar 

  • Nickavar B, Mojab F, Javidnia K, et al. Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran. Z Naturforsch C. 2003;58:629–31.

    Article  CAS  PubMed  Google Scholar 

  • Palhares RM, Gonçalves Drummond M, et al. Medicinal plants recommended by the world health organization: DNA barcode identification associated with chemical analyses guarantees their quality. PLoS One. 2015;10:e0127866.

    Article  PubMed  PubMed Central  Google Scholar 

  • Parhizkar S, Latiff LA. Supplementary health benefits of linoleic acid by improvement of vaginal cornification of ovariectomized rats. Adv Pharm Bull. 2013;3:31–6.

    PubMed  PubMed Central  Google Scholar 

  • Perveen T, Haider S, Kanwal S, et al. Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats. Pak J Pharm Sci. 2009;22:139–44.

    PubMed  Google Scholar 

  • Ramadan M. Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): an overview. Int J Food Sci Technol. 2007;42:1208–18.

    Article  CAS  Google Scholar 

  • Ramadan MF, Mörsel JT. Oxidative stability of black cumin (Nigella sativa L.), coriander (Coriandrum sativum L.) and niger (Guizotia abyssinica Cass.) crude seed oils upon stripping. Eur J Lipid Sci Technol. 2004;106:35–43.

    Article  CAS  Google Scholar 

  • Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005;5:1749–70.

    Article  CAS  PubMed  Google Scholar 

  • Salemal M, Hossain M. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int J Immunopharmacol. 2000;22:729–40.

    Article  Google Scholar 

  • Swamy SM, Tan BK. Cytotoxic and immunomodulatory effects of ethanolic extract of Nigella sativa L. seeds. J Ethnopharmacol. 2000;70:1–7.

    Article  CAS  PubMed  Google Scholar 

  • Taskin MM, Alankus Calis O, Anil H, et al. Triterpene saponins from Nigella sativa L. Turk J Chem. 2005;29:561–9.

    CAS  Google Scholar 

  • Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, et al. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol. 1991;31:283–9.

    Article  CAS  PubMed  Google Scholar 

  • Toparslan C. A propos de Nigella sativa L. Doctoral dissertation, Université de Lorraine; 2012.

    Google Scholar 

  • Ünal TD, Hamurcu Z, Delibaşı N, et al. Thymoquinone inhibits proliferation and migration of MDA-MB-231 triple negative breast cancer cells by suppressing autophagy, Beclin-1 and LC3. Anti Cancer Agents Med Chem. 2021;21:355–64.

    Article  Google Scholar 

  • Zaoui A, Cherrah Y, Alaoui K, et al. Effects of Nigella sativa fixed oil on blood homeostasis in rat. J Ethnopharmacol. 2002;79:23–6.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mehmet Berköz .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Berköz, M. (2022). Nigella sativa L.. In: Gürağaç Dereli, F.T., Ilhan, M., Belwal, T. (eds) Novel Drug Targets With Traditional Herbal Medicines. Springer, Cham. https://doi.org/10.1007/978-3-031-07753-1_29

Download citation

Publish with us

Policies and ethics