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Chemical Constituents of Ligularia Species (Asteraceae) and Their Diversity in East Asia

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Progress in the Chemistry of Organic Natural Products 113

Part of the book series: Progress in the Chemistry of Organic Natural Products ((POGRCHEM,volume 113))

Abstract

More than 100 Ligularia species and those of several related genera (Cremanthodium, Cacalia, Senecio, and others) in the plant family Senecioneae grow in East Asia. For many years, researchers have studied the chemical constituents of these plants, and terpenoids, flavonoids, sterols, alkaloids, and aromatic compounds have been isolated. Among these, in particular, numerous sesquiterpenoids were reported. In this contribution, relevant chemical studies are described mainly from literature reports appearing since 2000, inclusive of investigations performed by the present authors, on the diversity in secondary metabolites of Ligularia growing in the Hengduan Mountains area of China, focusing on eremophilane sesquiterpenoids and other metabolites. Terpenoids and aromatic compounds (totaling 1049), both new and known, are listed. Genetic studies and synthesis investigations are also reviewed briefly.

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Acknowledgments

We are indebted to Professor Yoshinori Asakawa, of Tokushima Bunri University, for his initial recommendation that we write this contribution and also for all of his subsequent encouragement. We also thank Professor Heinz Falk for his editorial guidance and many helpful suggestions. In addition, we are indebted to all those who have been involved in laboratory work, as carried out by our respective Ligularia species-related research team.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, Japan

    Motoo Tori

  2. Department of Chemistry, Rikkyo University, Tokyo, Japan

    Chiaki Kuroda

Authors
  1. Motoo Tori
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  2. Chiaki Kuroda
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Correspondence to Motoo Tori .

Editor information

Editors and Affiliations

  1. College of Pharmacy, Ohio State University, Columbus, OH, USA

    A Douglas Kinghorn

  2. Institute of Organic Chemistry, Johannes Kepler University, Linz, Oberösterreich, Austria

    Heinz Falk

  3. School of Pharmacy, University of East Anglia, Norwich, UK

    Simon Gibbons

  4. Graduate School of Pharmaceutical Science, Hokkaido University, Fukuoka, Japan

    Jun'ichi Kobayashi

  5. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Yoshinori Asakawa

  6. School of Pharmaceutical Sciences, South Central University for Nationaliti, Wuhan, China

    Ji-Kai Liu

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© 2020 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG

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Tori, M., Kuroda, C. (2020). Chemical Constituents of Ligularia Species (Asteraceae) and Their Diversity in East Asia. In: Kinghorn, A.D., Falk, H., Gibbons, S., Kobayashi, J., Asakawa, Y., Liu, JK. (eds) Progress in the Chemistry of Organic Natural Products 113. Progress in the Chemistry of Organic Natural Products, vol 113. Springer, Cham. https://doi.org/10.1007/978-3-030-53028-0_1

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