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Mesopotamia-Paranaense Forest

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Pharmacological Properties of Native Plants from Argentina

Abstract

The Mesopotamia, and particularly the Paranaense Forest, is briefly pictured regarding its geographical characteristics, weather, economical activities, fauna, and flora. In the reductions or missions settled by the Jesuits (San Ignacio Mini, Nuestra Señora de Santa Ana, Nuestra Señora de Loreto, Nuestra Señora de la Candelaria, Santa María la Mayor, Corpus Christi, Santos Apóstoles Pedro y Pablo, San José, San Javier de Yaguaraities, Nuestra Señora de la Concepción, Santos Mártires), in the province of MIS, the species of Ilex were cultured and commercialized for the first time. The species Cecropia pachystachya Trecul (Cecropiaceae), Anadenanthera colubrina (Vell.) Brenan var. cebil (Griseb.) Altschul, Ilex paraguariensis A. St.-Hil var. paraguariensis, Tabebuia impetiginosa (Mart. ex DC.) Standl., Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Hieron. ex Niederl., Passiflora caerulea L., Blechnum occidentale L., and Maytenus ilicifolia Mart. ex Reissek that grow in the Paranaense Forest are described in terms of their botanical characteristics, ethnomedical uses, chemicals, biological activity, toxicity, and establishment of in vitro cultures and legal status, when corresponding.

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References

  • Actis-Goretta L, Mackenzie GG, Oteiza PI, Fraga CG (2002) Comparative study on the antioxidant capacity of wines and other plant-derived beverages. Ann N Y Acad Sci 957(1):279–283

    Article  CAS  PubMed  Google Scholar 

  • Agra MF, Locatelli E, Rocha EA et al (1996) Plantas Medicinais dos Cariris Velhos, Paraíba, Brasil, Parte II: Subclasses Magnoliidae, Caryophyliidae, Dilleniida e Rosidae. Ver Bras Farm 77(1):97–102

    Google Scholar 

  • Ahmed MS, Fong HHS, Soejarto DD, Dobberstein RH, Waller DP, Moreno-Azorero R (1981) High-performance liquid chromatographic separation and quantitation of maytansinoids in Maytenus ilicifolia. J Chromatogr A 213(2):340–344

    Article  CAS  Google Scholar 

  • Alikardis F (1987) Natural constituents of Ilex species. J Ethnopharmacol 20:121–144

    Google Scholar 

  • Alonso J (2004) Tratado de Fitofármacos y Nutracéuticos. Corpus, Buenos Aires

    Google Scholar 

  • Alonso J, Desmarchelier CJ (2015) Plantas medicinales autóctonas de la Argentina. Bases científicas para su aplicación en atención primaria de la salud. 1a ed. – Ciudad Autónoma de Buenos Aires: Corpus Libros Médicos y Científicos

    Google Scholar 

  • Amat AG, Vajia ME (1991) Plantas medicinales y etnofarmacología en la provincia de Misiones (Argentina). Acta Farm Bonaer 10:153–159

    Google Scholar 

  • Amorín JL (1974) Plantas de la Flora Argentina relacionadas con alucinógenos americanos. Publicaciones de la Academia Argentina de Farmacia y Bioquímica 1:33–63

    Google Scholar 

  • Amorin JL, Rosow R (1988) Guia taxonómica con plantas de interés farmacéutico. Dominguezia 10(1):35–40

    Google Scholar 

  • Anesini C, Perez C (1993) Screening of plants used in argentine folk medicine for antimicrobial activity. J Ethnopharmacol 39:119–128

    Article  CAS  PubMed  Google Scholar 

  • Anesini C, Ferraro G, Filip R (2006) Peroxidase-like activity of Ilex paraguariensis. Food Chem 97:459–464

    Article  CAS  Google Scholar 

  • Anonimous (2017) La Misión. Los 30 pueblos guaraníes. Su estructura cultural y política. San Ignacio-Misiones-Argentina, pp 56

    Google Scholar 

  • Áquila S, Confort P, Spegazzini E, Volonté M, Debenedetti S. (2005) Determinación de flavonoides de Passiflora caerulea por TLC y HPLC para su control de calidad. 1° Congreso de Fitoterápicos del Mercosur. Montevideo, Uruguay. 28 nov-2 dic 2005

    Google Scholar 

  • Aragão DMO, Guarize L, Lanini J, da Costa JC, García RMG, Scio E (2010) Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats. J Ethnopharmacol 128:629–633

    Article  CAS  PubMed  Google Scholar 

  • Aragão DM, Lima IV, da Silva JM, Bellozi PM, da Costa J de C, Cardoso GM, de Souza-Fagundes EM, Scio E (2013) Anti-inflammatory, antinociceptive and cytotoxic effects of the methanol extract of Cecropia pachystachya Trecul. Phytother Res 27:926–930

    Google Scholar 

  • Arçari DP, Bartchewsky W, dos SantosTW OKA, Funck A, Pedrazzoli J, de Souza MF, Saad MJ, Bastos DH, Gambero A, Carvalho Pde O, Ribeiro ML (2009) Antiobesity Effects of yerba maté Extract (Ilex paraguariensis) in High-fat Diet–induced Obese Mice. Obesity 17:2127–2133. https://doi.org/10.1038/oby.2009.158

    Article  PubMed  Google Scholar 

  • Arcari DP, Bartchewsky W Jr, dos Santos TW, Oliveira KA, De Oliveira CC, Gotardo EM, Pedrazzoli J Jr, Gambero A, Ferraz LF, Carvalho Pde O et al (2011) Anti-inflammatory effects of yerba mate extract (Ilex paraguariensis) ameliorate insulin resistance in mice with high fat diet-induced obesity. Mol Cell Endocrinol 335:110–115

    Article  CAS  PubMed  Google Scholar 

  • Arcari DP, Santos JC, Gambero A, Ribeiro ML (2013a) The in vitro and in vivo effects of yerba mate (Ilex paraguariensis) extract on adipogenesis. Food Chem 141:809–815

    Article  CAS  PubMed  Google Scholar 

  • Arcari DP, Santos JC, Gambero A, Ferraz LF, Ribeiro ML (2013b) Modulatory effects of yerba mate (Ilex paraguariensis) on the PI3K-AKT signaling pathway. Mol Nutr Food Res 57:1882–1885

    CAS  PubMed  Google Scholar 

  • Arenas P (1997) Las fuentes actuales y del pasado para la etnobotánica del gran Chaco. Monograf Jard Bot Córdoba 5:17–25

    Google Scholar 

  • Argentina National Pharmacopeia (ANP) Codex Medicamentarius Argentino VIth edition (1978) 111–112

    Google Scholar 

  • Ariswa M, Morinaga Y, Nishi Y, UenoH SS, Hayashi T, Shimizu M, Yoshizaki M, Morita N, Berganza LH (1989) Chemical and pharmaceutical studies on medicinal plants:constituents of angiotensin converting enzyme inhibitory fraction from “Cocu,” Allophylus edulis RADLK. Shoyakugaku Zasshi 43:78–80

    Google Scholar 

  • Ashihara H (1993) Purine metabolism and the biosynthesis of caffeine in maté leaves. Phytochemistry 33(6):1427–1430

    Article  CAS  Google Scholar 

  • Baggio CH, Freitas CS, Otofuji GM, Cipriani TR, de Souza LM, Sassaki GL, Iacomini M, Andrade Marques MC, Mesia-Vela S (2007) Flavonoid-rich fraction of Maytenus ilicifolia Mart. ex. Reiss protects the gastric mucosa of rodents through inhibition of both H+, K+-ATPase activity and formation of nitric oxide. J Ethnopharmacol 113(3):433–330

    Article  CAS  PubMed  Google Scholar 

  • Baggio CH, Freitas CS, Twardowschy A, dos Santos AC, Mayer B, Potrich FB, Cipriani TR, Sassaki GL, Iacomini M, Marques MCA, Mesia-Vela S (2012) In vivo/in vitro Studies of the Effects of the Type II Arabinogalactan Isolated from Maytenus ilicifolia Mart. ex Reissek on the Gastrointestinal Tract of Rat. Z Naturforsch C 67:405–410

    Article  CAS  PubMed  Google Scholar 

  • Baltassat F, Darbour N, Ferry S (1984) Study on the purine levels in caffeine drugs. Plantes Medicinales et Phytotherapie 18:195–203

    CAS  Google Scholar 

  • Bandoni AL, Mendiondo ME, Rondina RV, Coussio JD (1972) Survey of Argentine medicinal plants. I Folklore and phytochemical screening Lloydia 35:69–80

    CAS  PubMed  Google Scholar 

  • Bandoni A (1976) Survey of Argentine medicinal plants. Folklore and Phytochemical Screening II. Econ Bot 30:161–166

    Article  Google Scholar 

  • Barboza GE, Cantero JJ, Núñez C, Pacciaroni A, Ariza Espinar L (2009) Medicinal Plants: A general review and a phytochemical and ethnopharmacological screening of the native Argentine Flora. Kurtziana 34(12):7365

    Google Scholar 

  • Barros ICL, Andrade LHC (1997) Pteridófitas medicinais (samambaias, avencas e plantas afins). Universitária da Universidade Federal de Pernambuco, Recife

    Google Scholar 

  • Bastos DHM, Ishimotoa EY, Marques MOM, Ferri F, Torres EAFS (2006) Essential oil and antioxidant activity of green mate and mate tea (Ilex paraguariensis) infusions. J Food Compos Anal 19:538–543

    Article  CAS  Google Scholar 

  • Berté AKAS, Beux MR, Spada PKWDS, Salvador M, Hoffman-Ribani R (2011) Chemical composition and antioxidant activity of yerba-mate (Ilex paraguariensis A.St.-Hil., Aquifoliaceae) extract as obtained by spray drying. J Agric Food Chem 59:5523–5527

    Article  CAS  PubMed  Google Scholar 

  • Bidau CJ, Amat AG, Yajía M, Martí DA, Riglos AG, Silvestroni A (2004) Evaluation of the Genotoxicity of aqueous extracts of Ilex paraguariensis St. Hil. (Aquifoliaceae) using the Allium Test. Cytologia 69(2):109–117

    Article  Google Scholar 

  • Bodrati A, Haene E (2004) Chal-chal o koku. Plantas que atraen aves, Chal-chal o Koku. Nat Conserv 26:16–17

    Google Scholar 

  • Bonfim Silva-Junior O, Grattapaglia D, Novaes E, Collevatti RG (2017) Genome assembly of the Pink Ipeˆ (Handroanthus impetiginosus, Bignoniaceae), a highly valued, ecologically keystone Neotropical timber forest tree. Gigascience 7:1–16

    Google Scholar 

  • Bracesco N, Dell M, Rocha A, Behtash S, Menini T, Gugliucci A, Nunes E (2003) Antioxidant activity of a botanical extract preparation of Ilex paraguariensis: prevention of DNA double-strand breaks in Saccharomyces cerevisiae and human low density lipoprotein oxidation. J Altern Complement Med 9(3):379–387

    Article  PubMed  Google Scholar 

  • Brango-Vanegas J, Costa GM, Ortmann CF, Schenkel EP, Reginatto FH, Ramos FA, Arévalo-Ferro C, Castellanos L (2014) Glycosyl flavonoids from Cecropia pachystachya Trécul are quor-um sensing inhibitors. Phytomedicine 21:670–675

    Article  CAS  PubMed  Google Scholar 

  • Brussa Santander CA, Grela González IA (2007) Flora arbórea del Uruguay: con énfasis en las especies de Rivera y Tacuarembó. COFUSA, Rivera (Uruguay)

    Google Scholar 

  • Buffa Filho W, Corsino J, da Silva BV, Furlan M, Pereira AMS, Castro França S (2002) Quantitative determination of cytotoxic -oleanane derivatives from five morphological types of Celastraceae by reverse-phase high-performance liquid chromatography. Phytochem Anal 13(2):75–78

    Article  CAS  PubMed  Google Scholar 

  • Buffa Filho W, Silva Bolzani V, Furlan M, Vaz Pereira SI, Soares Pereira AM, Castro França S (2004) In vitro propagation of Maytenus ilicifolia (Celastraceae) as potential source for antitumoral and antioxidant quinomethide triterpenes production. A rapid quantitative method for their analysis by reverse-phase high-performance liquid chromatography. Arkivoc 2004(vi):137–146

    Google Scholar 

  • Burris KP, Harte MH, Davidson PM, Neal Stewart C Jr, Zivanovic S (2012a) Composition and bioactive properties of yerba mate (Ilex paraguariensis A. St.-Hil.): a review. Chilean J Agric Res 72(2):268–274

    Article  Google Scholar 

  • Burris KP, Davidson PM, Stewart CN Jr, Zivanovic S, Harte FM (2012b) Aqueous extracts of yerba mate (Ilex paraguariensis) as a natural antimicrobial against Escherichia coli O157:H7 in a microbiological medium and pH 6.0 apple juice. J Food Prot 75(4):753–757

    Article  PubMed  Google Scholar 

  • Cabrera A (1965) Flora de la Provincia de Buenos Aires. Colección INTA. Tomo IV, Buenos Aires, pp 136–137

    Google Scholar 

  • Carlini EA, Macaubas CIP, Oliveira MGM, Barbosa VP (1988) Toxicologia préclínica da espinheira-santa (Maytenus ilicifolia). In: Carlini, ELA, coord. Estudo da ação antiúlcera gástrica de plantas Brasileiras (Maytenus ilicifolia “espinheira-santa” e outras). CEME/ AFIP, Brasília, p 49–66

    Google Scholar 

  • Cansian RL, Mossi AJ, Mosele SH, Toniazzo G, Treichel H, Paroul N, Oliveira JV, Oliveira D, Mazutti MA, Echeverrigaray S (2008) Genetic conservation and medicinal properties of mate Ilex paraguariensis St Hil. Pharmacognosy Rev 2:326–338

    Google Scholar 

  • Clifford MN, Ramirez-Martinez JR (1990) Chlorogenic acids and purine alkaloids contents of Maté (Ilex paraguariensis) leaf and beverage. Food Chem 35(1):13–21

    Article  CAS  Google Scholar 

  • Consolini AE, Migliorisi GN (2005) Cardiovascular effects of the South American medicinal plant Cecropia pachystachya (ambay) on rats. J Ethnopharmacol 96:417–422

    Article  PubMed  Google Scholar 

  • Consolini AE, Ragone MI, Migliori GN, Conforti P, Volonté MG (2006) Cardiotonic and sedative effects of Cecropia pachystachya Mart. (ambay) on isolated rat hearts and conscious mice. J Ethnopharmacol 106:90–96

    Article  PubMed  Google Scholar 

  • Cordeiro PJM, Vilegas JHY, Lanças FM (1999) HRGC-MS Analysis of Terpenoids from Maytenus ilicifolia and Maytenus aquifolium (“Espinheira Santa”). J Braz Chem Soc 10(6):523–526

    Article  CAS  Google Scholar 

  • Costa GM, Schenkel EP, Ortmann CF, Reginatto FH (2011) An HPLC-DAD method to quantification of main phenolic compounds from leaves of Cecropia species. Braz Chem Soc 26:1096–1102

    Article  Google Scholar 

  • Cunha SC (2003) Ação farmacológica da espinheira-santa: usos e precauções. Theses, Universidade Federal de Lavras, Brasil

    Google Scholar 

  • Cunha AL, Auharek SA, Oliveira RJ, Siqueira JM, Vieira MC, Leite VS, Portugal LC (2014) Effects of Maytenus ilicifolia on reproduction and embryo-fetal development in Wistar rats. Genetics and Molecular Research 13(2):3711–3720

    Article  CAS  PubMed  Google Scholar 

  • Debat HJ, Grabiele M, Aguilera PM, Bubillo RE, Otegui MB, Ducasse DA, Zapata PD, Marti DA (2014) Exploring the genes of yerba mate (Ilex paraguariensis A. St.-Hil.) by NGS and De Novo transcriptome assembly. PLoS One 9(10):e109835. https://doi.org/10.1371/journal.pone.0109835

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Deginani NB (2001) Las especies argentinas del género Passiflora (Passifloraceae). Darwin 39(1–2):43–129

    Google Scholar 

  • De Morais EC, Stefanuto A, Klein GA, Boaventura BC, de Andrade F, Wazlawik E, di Pietro PF, Maraschin M, da Silva EL (2009) Consumption of yerba mate (Ilex paraguariensis) improves serum lipid parameters in healthy dyslipidemic subjects and provides an additional LDL-cholesterol reduction in individuals on statin therapy. J Agric Food Chem 57:8316–8324

    Article  CAS  PubMed  Google Scholar 

  • De Resende PE, Kaiser S, Pittol V, Hoefel AL, D’ Agostini Silva R, Vieira Marques C, Kucharski LC, González Ortega G (2015) Influence of crude extract and bioactive fractions of Ilex paraguariensis A. St. Hil. (yerba mate) on the Wistar rat lipid metabolism. J Funct Foods 15:440–451

    Article  CAS  Google Scholar 

  • De Stefani E, Boffetta P, Deneo-Pellegrini H, Correa P, Ronco A, Brennan P, Ferro G, Acosta G, Mendilaharsu M (2007) Nonalcoholic beverages and risk of bladder cancer in Uruguay. BMC Cancer 29:7–57

    Google Scholar 

  • De Stefani E, Fierro L, Mendilaharsu M, Ronco A, Larrinaga M, Balbi J, Alonso S, Deneo-Pellegrini H (1998) Meat intake, ‘mate’ drinking and renal cell cancer in Uruguay: a case-control study. Br J Cancer 78:1239–1243

    Article  PubMed  PubMed Central  Google Scholar 

  • Dhawan K, Kumar S, Sharma A (2002) Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats. J Med Food 5:43–47

    Article  CAS  PubMed  Google Scholar 

  • Dhawan K, Dhawan S, Sharma A (2004) Passiflora: a review update. J Ethnopharmacol 94:1–23

    Article  CAS  PubMed  Google Scholar 

  • Díaz M, González A, Castro-Gamboa I, Gonzalez D, Rossini C (2008) First record of L-quebrachitol in Allophylus edulis (Sapindaceae). Carbohydr Res 343:2699–2700

    Article  CAS  PubMed  Google Scholar 

  • Díaz M, Castillo L, Diaz CE, Alvarez RG, González-Coloma A, Rossini C (2014) Differential deterrent activity of natural products isolated from Allophylus edulis (Sapindaceae). Adv Biol Chem 4:168–179. https://doi.org/10.4236/abc.2014.42021

    Article  CAS  Google Scholar 

  • Dittrich VAO, Heringer G, Salino A (2007) Blechnaceae. In: Cavalcanti, T.B.; Ramos, A.E. (org.). Vol. 6. Flora do Distrito Federal, Brasil. Embrapa Recursos Genéticos e Biotecnologia, Brasília pp 91–108

    Google Scholar 

  • Dittrich VAO, Salino A, Monteiro R (2015) The Blechnum occidentale (Blechnaceae, Polypodiopsida) species group in Southern and southeastern Brazil. Phytotaxa 231(3):201–229

    Article  Google Scholar 

  • Di Bitetti MS, Placci G, Dietz LA (2005) Situación ambiental en la ecorregión del bosque atlántico del Alto Paraná (selva paranaense) In: La situación ambiental Argentina 2005

    Google Scholar 

  • Domínguez JA, Soto M (1925) Monografías farmacológicas argentinas: el ambay. Trabajos del Instituto de Botánica y Farmacología, Editorial Peuser, Buenos Aires 43:1–47

    Google Scholar 

  • Duarte MR, Debur MC (2005) Stem and leaf morphoanatomy of Maytenus ilicifolia. Fitoterapia 76:41–49

    Article  CAS  PubMed  Google Scholar 

  • Duke JA, Bogenschutz-Godwin MJ, Ottesen AR (2009) Dukeís handbook of medicinal plants of Latin America. CRC Press, New York Taylor & Francis Group, Boca Raton, p 498

    Google Scholar 

  • Durán ML (1997) Estudios morfológicos, taxonómicos y biosistemáticos en el género Blechnum. Blechnaceae – Pteridophyta. Tesis doctoral. Universidad Nacional de Córdoba

    Google Scholar 

  • El-Askary HI, Haggag MY, Abou-Hussein DR, Hussein SM, Sleem AA (2017) Bioactivity guided study of Passiflora caerulea L. leaf extracts. Iran J Pharm Res 15:46–57

    Google Scholar 

  • Falconi A, Guitiérrez M, Benedetto L, Abin-Carriquiry JA, Bracesco N, Torterolo P (2013) Waking-promoting action of yerba mate (Ilex paraguariensis). Sleep Sci 6(1):0–00

    Google Scholar 

  • Fatori Trevizan LN, do Nascimento KF, Santos JA, Leite Kassuya CA, Lima Cardoso CA, Vieira MC, Martinez Figueira Moreira F, Croda J, Nazari Formagio AS (2016) Anti-inflammatory, antioxidante and anti- Mycobacterium tuberculosis activity of viridiflorol: the major constituent of Allophylus edulis (A.St.-Hil., A.J uss. & Cambess.) Radlk. J Ethnopharmacol 192:510–515

    Article  CAS  Google Scholar 

  • Farag MA, Otify A, Porzel A, Michel CG, Elsayed A, Wessjohann LA (2016) Comparative metabolite profiling and fingerprinting of genus Passiflora leaves using a multiplex approach of UPLC-MS and NMR analyzed by chemometric tools. Anal Bioanal Chem 408(12):3125–3143

    Article  CAS  PubMed  Google Scholar 

  • Feliu-Hemmelmann K, Monsalve F, Rivera C (2013) Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser. Int J Clin Exp Med 6:444–451

    PubMed  PubMed Central  Google Scholar 

  • Ferreira PM, Nonato de Oliveira C, Braga de Oliveira A, Lopez MJ, Alzamora F, Ribeiro Vieira MA (2004) A lyophilized aqueous extract of Maytenus ilicifolia leaves inhibits histamine-mediated acid secretion in isolated frog gastric mucosa. Planta 219:319–324

    Article  CAS  PubMed  Google Scholar 

  • Ferrucci MS (2004) Sapindaceae Juss. Aportes botánicos de Salta- Ser. Flora 7(4):1–45

    Google Scholar 

  • Figueredo FG, Ferreira EO, Lucena BFF, Torres CMG, Dl L, ECP L, JMFL S, FAV S, Medeiros CR, GMM O, Colares AV, JGM C, PRL F, EFF M (2013) Modulation of the antibiotic activity by extracts from Amburana cearensis A.C. Smith and Anadenanthera macrocarpa (Benth.) Brenan. BioMed Res Int 2013:640682. https://doi.org/10.1155/2013/640682

    Article  PubMed  Google Scholar 

  • Filip R, Ferraro G (2003) Researching on new species of Mate: Ilex brevicuspis. Phytochemical and pharmacology study. Eur J Nutr 42:50–54

    Article  CAS  PubMed  Google Scholar 

  • Filip R, López P, Coussio J, Ferraro G (1998) Mate substitutes or adulterants: study of Xanthine content. Phytother Res 12:129–131

    Article  CAS  Google Scholar 

  • Filip R, López P, Giberti G, Coussio J, Ferraro G (2001) Phenolic compounds in seven South American Ilex species. Fitoterapia 72:774–778

    Article  CAS  PubMed  Google Scholar 

  • Filip R, Lotito SB, Ferraro G, Fraga CG (2000) Antioxidant activity of Ilex paraguariensis and related species. Nutr Res 20:1437–1446

    Article  CAS  Google Scholar 

  • Fonseca C, Otto S, Paumgartten F, Leitão A (2000) Non-toxic, mutagenic, and clastogenic activities of mate-chimarrão (Ilex paraguariensis). J Environ Pathol Toxicol Oncol 19:333–346

    Google Scholar 

  • de Freitas Lima R, Ponchet Alves E, Rosalen PL, Tasca Gois Ruiz AL, Teixeira Duarte MC, Fernandes Furletti Góes V, Dantas de Medeiros AC, Vieira Pereira J, Pina Godoy G, Melo de Brito Costa EM (2014) Antimicrobial and Antiproliferative potential of Anadenanthera colubrina (Vell.) Brenan. Evid Based Complement Alternat Med 2014:1–7

    Article  Google Scholar 

  • Gamborg OL, Miller RA, Ojima K (1968) Nutrient requirements of suspension cultures of soybean root cells. Exp Cell Res 50(1):151–158

    Article  CAS  PubMed  Google Scholar 

  • Gazal M, Flach Ortmann C, Amelia Martins F, Streck EL, Quevedo J, Machado de Campos A, Stefanello FM, Kaster MP, Ghisleni G, Reginatto FH, Lencina CL (2014) Antidepressant-like effects of aqueous extract from Cecropia pachystachya leaves in a mouse model of chronic unpredictable stress. Brain Res Bull 108:10–17

    Article  PubMed  Google Scholar 

  • Gilman EF, Watson DG (1994) Tabebuia impetiginosa Purple Tabebuia. Forest Service US Department of Agriculture. Fact Sheet ST-617, pp 1–3

    Google Scholar 

  • Giraudo AR, Povedano H, BelgranoMJ KE, Pardiñas U, Miquelarena A, Ligier DH, Baldo D, Castelino M (2003) Biodiversity status of the Interior Atlantic Forest of Argentina. In: Galindo Leal C, De Gusmao CI (eds) The Atlantic Forest of South America: biodiversity status, threats and outlook (State of the Hotspots, 1). Center for Applied Biodiversity Science at Conser-vation International, Island Press, Washington, DC, pp 160–180

    Google Scholar 

  • Goncalves Silva RM, Saraiva TS, Boreli Silva R, Goncalves LA, Pereira Silva L (2010) Allelopathy potential of ethanolic extract of Anadenanthera macrocarpa and Astronium graveolens. Biosci J Uberlândia 26(4):632–637

    Google Scholar 

  • González de Mejía E, Song YS, Heck CI, Ramírez-Mares MV (2010) Yerba mate tea (Ilex paraguariensis): Phenolics, antioxidant capacity and in vitro inhibition of colon cancer cell proliferation. J Funct Foods 2:23–34

    Article  CAS  Google Scholar 

  • Gosmann G, Guillaume D, Toshirrico Cardoso Taketa A, Schenkel EP (1995) Triterpenoid Saponins from Ilex paraguariensis. J Nat Prod 58(3):438–441

    Article  CAS  PubMed  Google Scholar 

  • Grose SO, Olmstead RG (2007) Taxonomic revisions in the polyphyletic genus Tabebuia s. l. (Bignoniaceae). Syst Bot 32(3):660–670

    Article  Google Scholar 

  • Gupta MP (1995) 270 Plantas Iberoamericanas. Editorial Presencia, Colombia, pp 407–408

    Google Scholar 

  • Gutiérrez F, Estévez-Braun A, Ravelo AG, Astudillo L, Zárate R (2007) Terpenoids from the medicinal plant. J Nat Prod 70(6):1049–1052

    Article  CAS  PubMed  Google Scholar 

  • Hadas E, Ozarowski M, Derda M, Thiem B, Cholewinski M, Skrzypczak L, Gryszczynska A, Piasecka A (2017) The use of extracts from Passiflora spp. In helping the treatment of Acanthamoebiasis. Acta Pol Pharm Drug Res 74(3):921–928

    Google Scholar 

  • Hikawczuk V, Saad J, Guardia T, Juarez A, Giordano O (1998) Anti-inflammatory activity of compounds isolated from Cecropia pachystachya. Anal Asoc Quím Argentina 86:167–170

    Google Scholar 

  • Hoffmann-Bohm K, Lotter H, Seligmann O, Wagner H (1992) Antihepatotoxic -Glycosylflavones from the leaves of Allophyllus edulis var. edulis and gracilis. Planta Med 58(06):544–548

    Article  CAS  PubMed  Google Scholar 

  • Hurrell J, Bazzano D (2003). Arbustos 1: nativos y exóticos. Buenos Aires, L.O.L.A

    Google Scholar 

  • Hussain H, KrohnK AVU, Miana GA, Greend IR (2007) Lapachol: an overview. ARKIVOC 2(1):145–171

    Google Scholar 

  • Itokawa H, Shirota O, Ikuta H, Morita H, Takeya K, Itaka Y (1991) Triterpenes from Maytenus ilicifolia. Phytochemistry 30:3713–3716

    Article  CAS  Google Scholar 

  • Ivorra MD, Paya M, Villar A (1989) A review of natural products and plants as potent antidiabetic drugs. J Ethnopharmacol 27:243–275

    Article  CAS  PubMed  Google Scholar 

  • Jorge RM, Leite JPV, Oliveira AB, Tagliati CA (2004) Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia. J Ethnopharmacol 94:93–100

    Article  CAS  PubMed  Google Scholar 

  • Justiniano MJ, Fredericksen TS (1998) Curupaú Anadenanthera colubrina (Vell. Conc.) Benth. Mimosoideae In: Ecología y silvicultura de especies menos conocidas

    Google Scholar 

  • Körbes, VC (1995) Plantas medicinais, Francisco Beltrão: Associação de Estudos, Orientação e Assistência Rural (ASSESOAR) 51ed. p 188

    Google Scholar 

  • Kramer KU, Chambers TC, Hennipman E (1990). Blechnaceae. In: Kramer, K.U. & Green, P.S. (eds.). Pteridophytes and gymnosperms. In: Kubitzki, K. (ed). The families and genera of vascular plants. vol 1. Springer-Verlag, Berlin. pp 60–68

    Google Scholar 

  • Kraemer KH, Taketa ATC, Schenkel EP, Gosmann G, Guillaume D (1996) Matesaponin 5, a highly polar saponin from Ilex paraguariensis. Phytochemistry 42(4):1119–1122

    Article  CAS  PubMed  Google Scholar 

  • Kujawska M, Pieroni A (2015) Plants used as food and medicine by polish migrants in Misiones, Argentina. Ecol Food Nutr 54:255–279

    Article  PubMed  Google Scholar 

  • Lahitte HB, Hurrell JA, Valla JJ, Jankowski LS, Bazzano D, Hernández AJ (1999) Árboles urbanos. Biota Rioplatense IV. Inventario de la biota de la región del Delta del Paraná, Isla Martín García y Ribera Platense. Literature of Latin America (L.O.L.A.). Buenos Aires, Argentina. 320 p

    Google Scholar 

  • Lanzetti M, Bezerra FS, Romana-Souza B, Brando-Lima AC, Koatz VLG, Porto LC, Valenca SS (2008) Mate tea reduced acute lung inflammation in mice exposed to cigarette smoke. Nutrition 24:375–381

    Article  CAS  PubMed  Google Scholar 

  • Larraburu EE, Apóstolo NM, Llorente BE (2012) In vitro propagation of pink lapacho: response surface methodology and factorial analysis for optimization of medium components. Int J For Res 2012:1–9

    Google Scholar 

  • Leite JPV, Braga FC, Romussi G, Persoli RM (2010) Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity. J Braz Chem Soc 21:248–254

    Article  CAS  Google Scholar 

  • Lemos AO, Sanches JCM, Silva IEF, Silva MLA, Vinhólis AHC, Feliz MAP, Santos RA, Cecchi AO (2012) Genotoxic effects of Tabebuia impetiginosa (Mart. Ex DC.) Standl. (Lamiales, Bignoniaceae) extract in Wistar rats. Genet Mol Biol 35(2):498–502

    Article  PubMed  PubMed Central  Google Scholar 

  • Lima Fonseca W, de Almeida FA, Tiburtino Leite ML, Ap PR, Petter FA, de Oliveira AM, Martins Carvalho R, de Alcântara Neto F, Fernandes Pereira F, Mendonça Junior AF (2017) Bioactivity of aqueous extracts of Anadenanthera macrocarpa to Meloidogyne incognita in cotton crop. AJCS 11(02):156–161

    Google Scholar 

  • Lloyd GB, McCown BH (1980) Commercially-feasible micropropagation of mountain laurel, Kalmia latifolia, by use of shoot tip culture. Int Plant Prop Society Proc J 30:421–426

    Google Scholar 

  • Lopes da Silva Filho M (2007) Avaliação in vitro da ação antiparasitária do extrato aquoso e etanólico do angico preto (Anadenanthera macrocarpa) (Benth.) Brenan sobre o carrapato Rhipicephalus (Boophilus) microplus (Canestrini, 1887) / Dissertação (Mestrado) – Universidade Federal do Piauí

    Google Scholar 

  • Lopez da Silva Filho (2007) Avaliação in vitro da ação antiparasitária do extracto aquoso e etanólico do angico preto ( Anadenanthera macrocarpa) (Benth.) Brenan sobre o carrapato Rhipicephalus (Boophilus) microplus (Canestrini, 1887) Thesis Mestre em Ciência Animal, Área de Concentração: Clínica Médico – Cirúrgica de Animais de Interesse EconômicoEstado do Piauí – Brasil Agosto – 2007

    Google Scholar 

  • Lorenzi H, Matos FJA (2002a) Plantas Medicinais no Brasil: nativas e exóticas. Instituto Plantarum, São Paulo, pp 189–190

    Google Scholar 

  • Lorenzi H, Matos FJA (2002b) Plantas Medicinais no Brasil: nativas e exóticas. Instituto Plantarum, São Paulo, pp 189–190

    Google Scholar 

  • Luna CV, Gonález AM, Mroginski LA, Sansberro PA (2017) Anatomical and histological features of Ilex paraguariensis leaves under different in vitro shoot culture systems. Plant Cell Tiss Organ Cult 129(3):457–467. https://doi.org/10.1007/s11240-017-1191-x

    Article  Google Scholar 

  • Malizia LR, Cuykens E, Blundo C, Berno A, Pacheco S, Brown A (2018). http://www.ambienteforestalnoa.org.ar/userfiles/especies/pdf/Allophylusedulis.pdf

  • Maquiaveli CC, da Silva ER, Francescato HDC, Costa RS, Silva CGA, Casarini DE, Fonchi AF, Coimbra TM (2014) Brazilian embauba (Cecropia pachystachya) extract reduces renal lesionin 5/6 nephrectomized rats. J Renin Angiotensin Aldosterone Syst. 15 (4): 430-439

    Article  PubMed  Google Scholar 

  • Marini-Bettòlo GB, Nicoletti M, Patamia M, Galeffi C, Messana I (1981) Plant screening by chemical and chromatographic procedures under field conditions. J Chromatogr A 213(1):113–127

    Article  Google Scholar 

  • Martínez MAP, Pelloto JP, Basualdo N (1997) Distribution of flavonoid aglycones in Ilex species (Aquifoliaceae). Biochem Syst Ecol 25:619–622

    Article  Google Scholar 

  • Martínez-Crovetto RM (1987) Plantas reguladoras de la fecundidad utilizadas en la medicina popular del nordeste Argentino. Am Ind 47:279–293

    Google Scholar 

  • Martínez Crovetto R (1981) Plantas utilizadas en medicina en el N.O. de Corrientes. Fund. Miguel Lillo, Tucumán, 139 pp

    Google Scholar 

  • Martínez MR, Pochettino ML (1999) El valor del conocimiento etnobotánico local: aporte a la curricula educativa en el área de biología en las escuelas de Molinos. Valles Calchaquíes, provincia de Salta. Cuadernos del Instituto Nacional de Antropología y Pensamiento Latinoamericano 18:257–270

    Google Scholar 

  • Martin EE, Battezzati P, Bruno M, Sarroca D, Usero S, Bruno C (2006) Yerba mate (Ilex paraguariensis) como contraste oral negativo para colangiopancreatoresonancia. Estudio preliminar. Revista Argentina de Radiología 70(4):323–330

    Google Scholar 

  • Martins AG, Guterres SS, González Ortega G (2003) Anti-ulcer activity of spray-dried powders prepared from leaf extracts of Maytenus ilicifolia Martius ex Reiss. Acta Farm Bonaer 22(1):39–44

    Google Scholar 

  • Matos FJA (2ed) (1997) O Formulário fitoterápico do professor Dias da Rocha:informações sobre o emprego na medicina caseira, de plantas do Nordeste,especialmente do Ceará. Fortaleza: EUFC. method for broth dilution antifungal susceptibility testing of yeasts. Aproved standard – third edition M-27A3. Clinical and Laboratory Standards Institute, Wayne, PA

    Google Scholar 

  • Matsunaga K, Sasaki S, Ohizumi Y (1997) Excitatory and inhibitory effects of paraguayan medicinal plants Equisetum giganteum, Acanthospermum australe, Allophylus edulis and Cordia salicifolia on contraction of rabbit aorta and Guinea-pig left atrium. Nat Med 51:478–481

    Google Scholar 

  • Mechler E (2009) Tabebuia impetiginosa, Tabebuia avellanedae (Bignoniaceae). In: Medicinal plants in tropical countries II. Traditional Use-Experience-Facts. Christian Intercultural Health Ministries, Wettenberg, pp 1–9. http://www.mmh-mms.com/downloads/mp19tmpabebuiaimpetiginosa.pdf

  • Medina JH, Paladini AC, Wolfman C, Levide Stein M, Calvo D, Diaz LE, Pena C (1990) Chrysin (5,7-di-OH-flavone) a naturally occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol 40:2227–2231

    Article  CAS  PubMed  Google Scholar 

  • Mello Cruz E, da Silva ER, Maquiaveli CC, Sousa Sobral Alves E, Jr Lucon JF, Gonçalves dos Reis MB, Mendes de Toledo CE, Guaré Cruz F, Vannier-Santos MA (2013) Leishmanicidal activity of Cecropia pachystachya flavonoids: arginase inhibition and altered mitochondrial DNA arrangement. Phytochemistry 89:71–77

    Article  CAS  Google Scholar 

  • Mendonça ED, da Silva J, dos Santos MS, Carvalho P, Kick Mausolff Papke D, Flach Ortmann C, Picada JN, Reginatto FH, de Barros Falcao Ferraz A (2016) Genotoxic, mutagenic and antigenotoxic effects of Cecropia pachystachya Trécul aqueous extract using in vivo and in vitro assays. J Ethnopharmacol 193:214–220

    Article  PubMed  Google Scholar 

  • Miranda DD, Arcari DP, Pedrazzoli J Jr, Carvalho Pde O, Cerutti SM, DHM B, Ribeiro ML (2008) Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice. Mutagenesis 23(4):261–265

    Article  CAS  PubMed  Google Scholar 

  • Montanari T, de Carvalho JE, Dolder H (1998) Effect of Maytenus ilicifolia Mart. ex. Reiss on Spermatogenesis. Contraception 57:335–339

    Article  CAS  PubMed  Google Scholar 

  • Montanari T, Bevilacqua E (2002) Effect of Maytenus ilicifolia Mart. on pregnant mice. Contraception 65:171–175

    Article  PubMed  Google Scholar 

  • Moreau F (1973) Alcaloides y plantas alcaloideas. Oikos-Tau, Barcelona

    Google Scholar 

  • Morgan-Martins MI, Silva VS, Licks F, Colares JR, Schemitt EG, Forgiarini LF, Rosa DP, Marroni NP (2013) Ilex paraguariensis St. Hil. (yerba mate) improves the metabolic profile of and protects against oxidative stress in exercised and non-exercised rats. Int J Pharma Bio Sci 4(4):B1303–B1311

    Google Scholar 

  • Mors WB, Rizzini CT, Pereira NA (2000) Medicinal plants of Brazil. Reference Publications, Michigan

    Google Scholar 

  • Mosimann ALP, Wolhelm-Filho D, Silva EL (2006) Aqueous extract of Ilex paraguariensis (mate) attenuates the progression of atherosclerosis in cholesterol-fed rabbits. Biofactors 26:59–70

    Article  CAS  PubMed  Google Scholar 

  • Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassay with tobacco tissue cultures. Physiol Plant 15(3):473–497

    Article  CAS  Google Scholar 

  • Nakayama F (1966) Cultivo in vitro de tejidos de Passiflora caerulea. Revista de la Facultad de Agronomía de la Universidad Nacional de La Plata 42:63–74

    Google Scholar 

  • Newall CA, Anderson LA, Phillipson JD (1996) Herbal medicines. The Pharmaceutical Press, London, pp 189–190

    Google Scholar 

  • Niero R, Moser R, Busato ACB, Yunes RA, Reis A, Cechinel Filho V (2001) A comparative chemical study of Maytenus ilicifolia Mart. Reiss and Maytenus robusta Reiss (Celastraceae). Z. Naturforsch 56c:158–161

    Article  Google Scholar 

  • Nogueira L, Charvet Inckot R, de Oliveria SG, de Souza LA, Bona C (2011) Phytotoxicity of petroleum-contaminated soil and bio-remediated soil on Allophylus edulis. Rodriguésia 62(3):459–466

    Article  Google Scholar 

  • Nonato FR, Almeida Barros TA, Lucchese AM, Cordeiro Oliveira CE, Ribeiro dos Santos R, Pereira Soares MB, Villareeal CF (2009) Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract. J Ethnopharmacol 125:102–107

    Article  PubMed  Google Scholar 

  • Nunes LE, Porto Viana AP, Vieira da Rocha RV, Sena Cunha VD, Ramalho Catao RM, Melo de Brito Costa EM (2015) In vitro evaluation of antifungal activity and interactive effect of Anadenanthera colubrina (Benth). Afr J Microbiol Res 9(36):2006–2012

    Google Scholar 

  • Ohsaki A, Imai Y, Naruse M, Ayabe S, Komiyama K, Takashima J (2004) Four new triterpenoids from Maytenus ilicifolia. J Nat Prod 67(3):469–471

    Article  CAS  PubMed  Google Scholar 

  • Oliveira MG, Monteiro MG, Macaubas C, Barbosa VP, Carlini EA (1991) Pharmacologic and toxicologic effects of two Maytenus species in laboratory animals. J Ethnopharmacol 34:29–41

    Article  CAS  PubMed  Google Scholar 

  • Oyarzabal M, Clavijo J, Oakley L, Biganzoli F, Tognetti P, Barberis I, Maturo HM, Aragón R, Campanello PI, Prado D, Oesterheld M, León RJC (2018) Unidades de vegetación de la Argentina. Ecol Austral 28(1):040–063

    Article  Google Scholar 

  • Palmeira JD, Ferreira SB, SOUZA JH, Almeida JM, Figueiredo MCP, Pequeno AS, Arruda TA, Antunes RMP, Catão RMR (2010) Avaliação da atividade antimicrobiana in vitro e determinação da concentração inibitória mínina (CIM) de extratos hidroalcóolico de angico sobre cepas de Staphylococcus aureus. Rev Bras Anal Clin 42:33–38

    Google Scholar 

  • Pasquali TR, Macedo SMD, Roman SS, Dal Prá V, Cansian RL, Mossi AJ, Oliveira VJ, Mazutti MA (2011) Acute toxicity and anti inflammatory effects of supercritical extracts of Ilex paraguariensis. Afr J Pharm Pharmacol 5(8):1162–1169

    Google Scholar 

  • Park B-S, Lee K-G, Shibamoto T, Lee S-E, Takeoka GR (2003) Antioxidant activity and characterization of volatile constituents of Taheebo (Tabebuia impetiginosa Martius ex DC). J Agric Food Chem 51:295–300

    Article  CAS  PubMed  Google Scholar 

  • Park B-S, Lee K-K, Lee S-E, Piao X-L, Takeoka GR, Wong RY, Ahn YJ, Kim JH (2006) Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori. J Ethnopharmacol 105:255–262

    Article  CAS  PubMed  Google Scholar 

  • Paroul N, Buogo de Jesús G, Atti Serafini L, Moyna P, Cancian R (2002) Essential oils from two different populations of Ilex paraguariensis. Trabajo presentado en el 1° Congreso Latinoamericano de Fitoquímica. Buenos Aires

    Google Scholar 

  • Pérez Gollán JÁ, Gordillo I (1993) Alucinógenos y sociedades indígenas del noroeste argentino. Anales de Antropología 30:299–350

    Google Scholar 

  • Pereira AMS, Rodrigues DC, Cerdeira RM, de M França SC (1992) Isolamento de metabólitos de Maytenus associados à ação anti-úlcera gástrica. XII Simpósio de Plantas Medicinais Brasileiras. Anais, p 55 UPFR, Curitiba, Brazil

    Google Scholar 

  • Pereira C, Yariwake J, Lancas F, Wauters J, Tits M, Angenot L (2004) A HPLC densitometric determination of flavonoids from Passiflora alata, P. edulis, P. incarnata and P. coerulea and comparison with HPLC method. Phytochem Anal 15:241–248

    Article  CAS  PubMed  Google Scholar 

  • Pereira MAS, Januário AH, Queiroz MEE, Biondo R, França SC (2005) Evaluation of Maytenus aquifolia Mart. and Maytenus ilicifolia Mart. chemotypes for tannins, total phenols and triterpenes. Rev Bras Pl Med, Botucatu 8(1):13–17

    CAS  Google Scholar 

  • Pérez JM, Maldonado ME, Rojano BA, Alzate F, Sáez J, Cardona W (2014) Comparative antioxidant, antiproliferative and apoptotic effects of Ilex laurina and Ilex paraguariensis on Colon Cancer cells. Trop J Pharm Res 13(8):1279–1286

    Google Scholar 

  • Perez-Guerrero C, Herrera MD, Ortiz R, Alvarez de Sotomayor M, Fernandez MA (2001) A pharmacological study of Cecropia obtusifolia Bertol aqueous extract. J Ethnopharmacol 76:279–284

    Article  CAS  PubMed  Google Scholar 

  • Pérez Ibáñez NM, Tillett S, Taddei A (2017) C-Glucosylflavone of three species of the genus Passiflora. Antibacterial, antioxidant activity and quantification. Revista de la Facultad de Farmacia, Universidad Central de Venezuela 79(1–2):68–76

    Google Scholar 

  • Pessôa Santiago AC, Carneiro Leão Barros I, de Oliveira Dittrich VA (2014) Ferns and lycophytes of Pernambuco state, Brazil: Blechnaceae. Rodriguésia 65(4):861–869

    Article  Google Scholar 

  • Petenatti ME, Gette MA, Popovich MC, Garro MF, Camí G, Aragón L, Del Vitto LA, Petenatti EM (2014) Identificación de C-glicosilflavonas por HPLC y FTIR en extractos acuoso y metanólico de Passiflora caerulea y P. foetida (Passifloraceae). Dominguezia 30(1):35–40

    Google Scholar 

  • Piacente S, Balderrama L, De Tommasi N, Morales L, Vargas L, Pizza C (1999) Anadanthoside: a favanol-3-O-β-D-xylopyranoside from Anadenanthera macrocarpa. Phytochemistry 51:709–711

    Article  CAS  Google Scholar 

  • Pires TCSP, Dias MI, Calhelha RC, Carvalho AM, Queiroz MJRP, Barros L, CFR F (2015) Bioactive Properties of Tabebuia impetiginosa-Based Phytopreparations and Phytoformulations: A Comparison between Extracts and Dietary Supplements. Molecules 20:22863–22871. https://doi.org/10.3390/molecules201219885

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Placci LG, Giorgis P (1994) Estructura y diversidad de la selva del Parque Nacional Iguazú, Argentina, VII Jornadas Técnicas sobre Ecosistemas Forestales Nativos: Uso, Manejo y Conservación, El Dorado, pp 123–138

    Google Scholar 

  • Ponce MM (1996) Pteridophyta. In: Zuloaga, F.O. & Morrone, O. (eds.) Catálogo de las plantas vasculares de la República Argentina. I: Pteridophyta, Gymnospermae y Angiospermae (Monocotyledoneae). Monographs in Systematic Botany from the Missouri Botanical Garden 60: i–xviii, 1–323

    Google Scholar 

  • Puangpraphant S, Berhow MA, de Mejjía G (2011) Mate (Ilex paraguariensis St. Hilaire) saponins induce caspase-3-dependent apoptosis in human colon cancer cells in vitro. Food Chem 125:1171–1178

    Article  CAS  Google Scholar 

  • Ragonese A, Milano V (1984) Vegetales y Sustancias Tóxicas de la Flora Argentina. In: Enciclopedia Argentina dela Agricultura y Jardinería, 2nd edn. Edit. Acme, Buenos Aires, pp 256–257

    Google Scholar 

  • Rastogi RP, Mehrotra BN (1990) Compendium of Indian Medicinal plants CDRI Lucknow and, CSIR, New Delhi, 1990; 1:25

    Google Scholar 

  • Ratera EL, Ratera MO (1980) Plantas de la flora argentina empleadas en medicina popular. Ed. Hemisferio sur S. A., Buenos Aires

    Google Scholar 

  • Reginatto F, Kauffman C, Schripsema J, Guillaume D, Gosmann G, Schenkel EP (2001) Steroidal and triterpenoidal glucosides from Passiflora alata. J Braz Chem Soc 12:32–36

    Article  CAS  Google Scholar 

  • Resico C (2007) Estado actual de la informacion sobre productions forestales no madereros. Food and Agriculture Organization of the United Nations. http://www.fao.org//OCREP//oo6//AD3935//AD393s13.htm (accessed 22 nov 2007).\par

  • Ricco RA, Wagner ML, Gurni AA (1991) Estudio comparativo de flavonoides en seis especies austrosudamericanas del género Ilex. Acta Farm Bonaer 10:29–35

    CAS  Google Scholar 

  • Rodrigues de Almeida E (2009) Preclinical and clinical studies of Lapachol and Beta-Lapachone. Open Nat Prod J 2:42–47

    Article  CAS  Google Scholar 

  • Rondina RVD, Al B, Coussio JD (2006) Especies medicinales argentinas con potencial actividad analgésica. Dominguezia 24(1):47–69

    Google Scholar 

  • Ross S, Arriaga ME, Pechi E (2017) Establecimiento in vitro de Yerba mate (Ilex paraguariensis A. St.-Hil.) nativa de Uruguay. Agrociencia Uruguay 21(1):15–23

    Google Scholar 

  • Ruxton CHS, Kirkwood L, McMillan B, St John D, Evans CEL (2007) Effectiveness of a herbal weight loss supplement (Zotrim™) for weight management. Br Food J 109(6):416–428

    Article  Google Scholar 

  • Saldaña MDA, Mohamed RS, Baer MG, Mazzafera P (1999) Extraction of purine alkaloids from maté (Ilex paraguariensis) using supercritical CO2. J Agric Food Chem 47:3804–3808

    Article  CAS  PubMed  Google Scholar 

  • Saldaña MDA, Zetzl C, Mohamed RS, Brunner G (2002) Extraction of methylxanthines from guaraná seeds, maté leaves, and cocoa beans using supercritical carbon dioxide and ethanol. J Agric Food Chem 50:4820–4826

    Article  CAS  PubMed  Google Scholar 

  • Santos-Oliveira R, Coulaud-Cunha S, Colaçao W (2009) Revisão da Maytenus ilicifolia Mart. ex Reissek, Celastraceae. Contribuição ao estudo das propriedades farmacológicas. Braz J Pharm 19(2B):650–659

    Article  Google Scholar 

  • Santos VAFFM, Regasini LO, Nogueira CR, Passerini GD, Martínez I, Bolzani VS, Graminha M, Cicarelli RMB, Furlan M (2012) Antiprotozoal Sesquiterpene pyridine alkaloids from Maytenus ilicifolia. J Nat Prod 75(5):991–995

    Article  CAS  PubMed  Google Scholar 

  • Scheffer MC, Corrêa Júnior C, Radomski M (2005) Domesticaçao de plantas medicinais: a experiencia da espinheira-santa (Maytenus ilicifolia Mart ex Reiss). Agrociencia IX(1, 2):53–59

    Google Scholar 

  • Schenkel E, Montanha J, Gosman G (1996) Triterpene saponins from mate, Ilex paraguariensis. Adv Exp Med Biol 405:47–56

    Article  CAS  PubMed  Google Scholar 

  • Schinella G, Aquila S, Dade M, Giner R, Recio Me C, Spegazzini E, de Buschiazzo P, Tournier H, Ríos JL (2008) Anti-inflammatory and apoptotic activities of pomolic acid isolated from Cecropia pachystachya. Planta Med 74:215–220

    Article  CAS  PubMed  Google Scholar 

  • Schultes RE, Hofman A (1993) Les plantes des dieux. Ed du Lézard, France

    Google Scholar 

  • Schulze M, Grogan J, Uhl C, Lentinia M, Vidal E (2008) Evaluating ipeˆ (Tabebuia, Bignoniaceae) logging in Amazonia: sustainable management or catalyst for forest degradation? Biol Conserv 141:2071–2085

    Article  Google Scholar 

  • Seigler DS, Spencer KC, Statier WS, Conn EE, Dunn JE (1982) Tetraphyllin B and epitetraphyllin B sulphates: novel cyanogenic glucosides from Passiflora caerulea and P. alato-caerulea. Phytochemistry 21:2277–2282

    Article  CAS  Google Scholar 

  • Şesan TE, Sarbu A, Smarandache D, Oancea F, Oancea A, Savin S, Toma A, Ştefan L, Negru G, Bira AF, Vlascenau G, Ghiurea M, Jecu L, Vasilescu G, Pomaohaci CM (2016) Botanical and phytochemical approach on Passiflora spp. – new nutraceutical crop in Romania. J Plant Develop 23:97–126

    Google Scholar 

  • Severin C, Bueno M, Santin F, Giubileo G (2011) Respuesta in vitro de diferentes biotipos y explantos de Passiflora caerulea L. Rev Colomb Biotecnol 13(1):73–79

    Google Scholar 

  • Shirota O, Morita H, Takeya K, Itokawa H (1994) Cytotoxic aromatic triterpenes from Maytenus ilicifolia and Maytenus ilicifolia. J Nat Prod 57:1675–1681

    Article  CAS  PubMed  Google Scholar 

  • Silva C, Récio R (1992) Coleta e avaliação dos compostos fitoquimicos da espinheira santa (Maytenus ilicifolia). Comunicacion al XII Simpósio de Plantas Medicinais do Brasil. Curitiba, Brasil

    Google Scholar 

  • Silva MAB (2009) Levantamento etnobotânico e triagem hipolipidêmica de plantas medicinais do Cerrado matogrossense: avaliação da atividade hipolipidêmica da Simaba ferruginea St. Hil. e Vochysia ru-fa Mart [dissertação]. Cuiabá: Faculdade de Ciências Médicas, Uni-versidade Federal de mato Grosso

    Google Scholar 

  • Soares LAL, Oliveira AL, González Ortega G, Petrovick PR (2004) Development and validation of a LC-method for determination of catechin and epicatechin in aqueous extractives from leaves of Maytenus ilicifolia. J Pharm Biomed Anal 36(4):787–790

    Article  CAS  PubMed  Google Scholar 

  • Soraru SB, Bandoni AL (1978) Plantas de la medicina popular argentina. Editorial Albatros, Buenos Aires, pp 76–78

    Google Scholar 

  • de Sousa NC, de Rezender AA, da Silva RMG, Guterres ZR, Gral U, Kerr WE, Spano MA (2009) Modulatory effects of Tabebuia impetiginosa (Lamiales, Bignoniaceae) on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster. Genet Mol Biol 32(2):382–388

    Article  PubMed  PubMed Central  Google Scholar 

  • Souza-Formigoni MLO, Oliveira MGM, Goldnadel Monteiro M, Gomes da Silveira-Filho N, Braz S, Carlini EA (1991) Antiulcerogenic effects of two Maytenus species in laboratory animals. J Ethnopharmacol 34:21–27

    Google Scholar 

  • Speroni E, Billi R, Perellino NC, Minghetti A (1996) Role of chrysin in the sedative effects of P. incarnata L. Phytother Res 10:S98–S100

    CAS  Google Scholar 

  • Suo M, Ohta T, Takano F, Jin S (2013) Bioactive phenypropanoid glycosides from Tabebuia avellanedae. Molecules 18:7336–7345

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Taketa ATC, Breitmaier E, Schenkel EP (2004) Triterpenes and triterpenoidal glycosides from the fruits of Ilex paraguariensis (Maté). J Braz Chem Soc 15:205–211

    Article  CAS  Google Scholar 

  • Tirloni CAS, Macorini LFB, dos Santos UP, da Rocha PS, Barros SV, de Melo AMMF, Vieira MC, Souza KP, dos Santos EL (2015a) Evaluation of the antioxidant activity, antimicrobial effect and acute toxicity from leaves of Allophylus edulis A. St.-Hil., A. Juss. Cambess & Hieron. ex Niederl. Afr J Pharm Pharmacol 9(11):353–362

    Article  CAS  Google Scholar 

  • Tirloni CAS, Traesel GK, Costa HMG, Victol NS, Takegava VF, Donatini RS, Souza KP, Santos EL (2015b) Chemical profile and evaluation of acute toxicity of Allophylus edulis A. St.-Hil., A. Juss. Cambess & Hieron. ex Niederl. 23rd Congress of the International Union for Biochemistry and Molecular Biology 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology Foz do Iguaçu, PR, Brazil, August 24th to 28th, 2015

    Google Scholar 

  • Tryon RM, Tryon A (1982) Ferns and allied plants, with special reference to tropical America. Springer Verlag, New York

    Book  Google Scholar 

  • Toursarkissian M (1980) Plantas Medicinales de la Argentina. Ed. Hemisferio Sur, Buenos Aires, Argentina

    Google Scholar 

  • Turner S, Cogoi L, Isolobella S, Filip R, Anesini C (2011) Evaluation of the antioxidant activity and polyphenols content of Ilex paraguariensis (mate) during industrialization. Adv J Food Sci Technol 3(1):23–30

    Google Scholar 

  • Tyler V (1987) The new honest herbal. Stickley G Co (Ed), Philadelphia (PA)

    Google Scholar 

  • Uchoa VT, de Paula RC, Krettl LG, Santana AEG, Krettli AU (2010) Antimalarial activity of compounds and mixed fractions of Cecropia pachystachya. Drug Dev Res 71:82–91

    CAS  Google Scholar 

  • Varela G, Cocucci A, Sérsic NA (2016) Función de la corona en Passiflora caerulea (Passifloraceae) como atrayente de sus vectores de polinización. Bol Soc Argent Bot 51(1):99–110

    Article  Google Scholar 

  • Vasconcelos CM, Chaves Vasconcelos TL, Póvoas Fabiani Tenório X, Evangelista Pires dos Santos RD, da Costa Maynart WH, Gomes de Almeida T, Fragoso da Silva Oliveira J, Dalboni França AD, Sales Santos Veríssimo RC, Lins Thais H, de Araújo-Júnior JX, de Assis Bastos ML (2014) Antimicrobial, antioxidant and cytotoxic activity of extracts of Tabebuia impetiginosa (Mart. ex DC.) Standl. J Chem Pharm Res 6(7):2673–2681

    Google Scholar 

  • Vassallo A, Correa P, De Stefani E, Cendan M, Zavala D, Chen V, Carzoglio J, Deneo-Pellegrini H (1985) Esophageal cancer in Uruguay: a case-control study. J Natl Cancer Inst 75:1005–1009

    CAS  PubMed  Google Scholar 

  • Velázquez E, Tournier HA, Mordujovich de Buschiazzo P, Saavedra G, Schinella GR (2003) Antioxidant activity of Paraguayan plant extracts. Fitoterapia 74:91–97

    Article  PubMed  Google Scholar 

  • Vera García R, Basualdo I, Peralta I, de Herebia M, Caballero S (1997) Minerals content of Paraguayan yerba mate (Ilex paraguariensis). Arch Latinoam Nutr 47:77–80

    PubMed  Google Scholar 

  • Viglione A, Vallejo N (2011) CEBIL: an American hallucinogenic plant in Botany books by different authors. 40th international congress for the history of pharmacy. September 2011, Berlin, Germany

    Google Scholar 

  • Wnuk M, Lewinska A, Oklejewicz B, Bugno M, Slota E, Bartosz G (2009) Evaluation of the cyto- and genotoxic activity of yerba mate (I lex paraguariensis ) in human lymphocytes in vitro. Mutat Res Genet Toxicol Environ Mutagen 679(1–2):18–23

    Article  CAS  Google Scholar 

  • Wolfman C, Viola H, Paladini A, Dajas F, Medina JH (1994) Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora caerulea. Pharmacol Biochem Behav 47:1–4

    Article  CAS  PubMed  Google Scholar 

  • Woodrow A (1985) Los Jesuitas. Historia de un dramático conflicto Sudamericana-Planeta, pp 186

    Google Scholar 

  • Yajía ME, Martí DA, Bidau CJ, Amat AG, Riglos AG, Silvestroni A (1999) Genotoxicity evaluation of Allophylus edulis (Camb.) Radlk. (Sapindaceae) aqueous extract. Acta Hortic 501:31–36

    Article  Google Scholar 

  • Zanon de Moura M, Pádua LE, Ramalho e Silva PR, Silva AA, Maggioni K (2012) Extrato de folhas de Anadenanthera macrocarpa sobre a biologia de Spodoptera frugiperda criada em dieta artificial. Comunicata Scientiae 3(4):249–254

    Google Scholar 

  • Zuloaga F, Morrone O, Belgrano M (2000) Características biogeográficas de la provincia de Misiones, Instituto de Botánica Darwinion, Informe para Fundación Vida Silvestre Argentina

    Google Scholar 

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  1. Department of Biotecnología Vegetal,, CONICET/ CEBBAD Universidad Maimónides, Ciudad de Buenos Aires, Argentina

    María Alejandra Alvarez

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  1. María Alejandra Alvarez
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Alvarez, M.A. (2019). Mesopotamia-Paranaense Forest. In: Pharmacological Properties of Native Plants from Argentina. Springer, Cham. https://doi.org/10.1007/978-3-030-20198-2_5

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