Abstract
Arthritis is a frequent autoimmune disease with undefined etiology and pathogenesis. Scientific community constantly fascinating quercetin (QUR), as it is the best-known flavonoid among others for curative and preventive properties against a wide range of diseases. Due to its multifaceted activities, the implementation of QUR against various types of arthritis namely, rheumatoid arthritis (RA), osteoarthritis (OA), gouty arthritis (GA) and psoriotic arthritis (PsA) has greatly increased in recent years. Many research evidenced that QUR regulates a wide range of pathways for instance NF-κB, MAK, Wnt/β-catenine, Notch, etc., that are majorly associated with the inflammatory mechanisms. Besides, the bioavailability of QUR is a major constrain to its therapeutic potential, and drug delivery techniques have experienced significant development to overcome the problem of its limited application. Hence, this review compiled the cutting-edge experiments on versatile effects of QUR on inflammatory diseases like RA, OA, GA and PsA, sources and bioavailability, therapeutic challenges, pharmacokinetics, clinical studies as well as toxicological impacts. The use of QUR in a health context would offer a tearing and potential therapeutic method, supporting the advancement of public health, particularly, of arthritic patients worldwide.
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Abbreviations
- AIM2:
-
Absent in melanoma 2
- ADME:
-
Absorption, distribution, metabolism, and excretion
- ADA:
-
Adenosine deaminase
- AIA:
-
Adjuvant-induced arthritic
- ALP:
-
Alkaline phosphatase
- ASC:
-
Apoptosis-associated speck-like protein containing CARD
- CaC2O4 :
-
Calcium oxalate
- CCL:
-
C–C motif chemokine ligand
- JNK:
-
C-Jun N-terminal kinase
- CD14:
-
Cluster of differentiation14
- CoPP:
-
Cobalt protoporphyrin IX
- CIA:
-
Collagen-induced arthritic
- C3:
-
Complement protein 3
- CFA:
-
Complete Freund adjuvant
- COX:
-
Cyclooxygenase
- E-ADA:
-
Ectoadenosine deaminase
- ENM:
-
Electrospun nanofiber membrane
- ECM:
-
Extracellular matrix
- FLS:
-
Fibroblst like synovium
- GATA6:
-
GATA transcription factor 6
- GO:
-
Gene ontology
- GA:
-
Gout arthritis
- HO:
-
Heme oxygenase
- H:
-
Hydrogen
- HIF-1:
-
Hypoxia-inducible factor-1
- iNOS:
-
Inducible nitric oxide synthase
- IL:
-
Interleukin
- KOA:
-
Knee-OA
- KEGG:
-
Kyoto Encyclopedia of Genes and Genomes
- LII:
-
Limb idleness index
- LOX:
-
Lipooxigenase
- LPS:
-
Lipopolysaccharides
- M1:
-
Secretes pro-inflammatory cytokines
- M2:
-
Secretes anti-inflammatory cytokines
- MMPs:
-
Matrix metalloproteinases
- MTX:
-
Methotrexate
- mPEG-PA:
-
Methyl-poly(ethylene glycol)-l-poly(alanine)
- MIA:
-
Monoiodoacetate
- MSU:
-
Monosodium urate
- MPO:
-
Myeloperoxidase
- NK:
-
Natural killer cells
- NO:
-
Nitric oxide
- NLRP3:
-
NLR protein3
- NLR:
-
Nod-like receptor
- Nrf2:
-
Nuclear factor erythroid2-related factor
- RANKL:
-
Nuclear factor kappa-Β ligand
- NF:
-
Nuclear factor
- OAT1:
-
Organic anion transport1
- OA:
-
Osteoarthritis
- P2X7R:
-
P2X, NLRP3, ligand-gated ion channel7
- PG:
-
Prostaglandin
- PsA:
-
Psoriatic arthritis
- QUR:
-
Quercetin
- ROS:
-
Reactive oxygen species
- CRP:
-
Reactive protein C
- RA:
-
Rheumatoid arthritis
- RF:
-
Rheumatoid factor
- SMP:
-
Sanmiao pill
- SASP:
-
Senescence-associated secretary phenotype
- SMP:
-
Simiao Powder
- TMJ:
-
Temporomandibular joint
- TBHP:
-
Tert-butyl hydroperoxide
- TXNIP:
-
Thioredoxin interacting protein
- TIMP1:
-
Tissue inhibitor matrix metalloproteinase1
- TLR4:
-
Toll-like receptor4
- TCM:
-
Traditional Chinese medicines
- TNF-α:
-
Tumor necrosis factor
- VEGF:
-
Vascular endothelial growth factor
- XFG:
-
Xiaofeng Granule
- ZSD:
-
ZishengShenqi Decoction
- ZIA:
-
Zymosan-induced arthritic
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Acknowledgements
The authors would like to thank the University Grants Commission, New Delhi, and Council of Scientific and Industrial Research, New Delhi, for awarding fellowship to Anita Bhoi under Research Fellowship [F.No. 16-6(DEC. 2018)/2019(NET/CSIR), dated July 24, 2019]. The author would also like to acknowledge DHR-ICMR project no: V.25011/286-HRD/2016-HR for financial support.
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The authors would like to thank the University Grants Commission, New Delhi, and the Council of Scientific and Industrial Research, New Delhi, for awarding a fellowship to Anita Bhoi under Research Fellowship [F.No. 16–6(DEC. 2018)/2019(NET/CSIR), dated July 24, 2019]. The author would also like to acknowledge DHR-ICMR project no: V.25011/286-HRD/2016-HR for financial support.
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Bhoi, A., Dwivedi, S.D., Singh, D. et al. Mechanistic prospective and pharmacological attributes of quercetin in attenuation of different types of arthritis. 3 Biotech 13, 362 (2023). https://doi.org/10.1007/s13205-023-03787-6
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DOI: https://doi.org/10.1007/s13205-023-03787-6