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Comparative Study on Phytochemical Profiles, Antiproliferative, Antimicrobial and Antioxidant Activities of Adonis Species from Turkey

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Pharmaceutical Chemistry Journal Aims and scope

The present study aimed to determine antiproliferative, antimicrobial, antioxidant activities and also phytochemical composition of different nine Adonis L. species from Turkey. Leaves extracts of the plant samples were used to evaluate antimicrobial activity against 7 bacteria and 2 yeast strains using MICs and disc-diffusion methods. The antioxidant activity of plant samples was determined by using DPPH radical scavenging activity method. MTT assay was used for evaluation antiproliferative activities of the extracts against HL-60, HCA-7 and HUVEC human cells. Chemical composition of plant extracts were determined by Gas Chromatography/Mass Spectrometry. The antimicrobial analyses results showed Gram-negative bacteria more sensitive than Gram-positive against the extracts, and the values were varied from 3.1 to 13.4 μg/mL. The leaf extract of different Adonis species exhibited remarkable antiproliferative activities towards tested human cancer cells in a dose and time dependently, and they were found to possess more antiproliferative activity against HL-60 cells than that of the HCA-7 cells. As for the chemical composition of Adonis species, they were found to contain many components with antimicrobial and beneficial effects, such as ethyl palmitate, ethyl linoleate. Overall, it was concluded that leaves extracts of Adonis species could have a great potential for use in medicinal drug sources.

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Authors and Affiliations

  1. Department of Biology, Faculty of Science and Literature, Hatay Mustafa Kemal University, 31060, Hatay, Turkey

    Faruk Karahan & Ahmet Ilcim

  2. Department of Biology, Faculty of Science and Literature, Sinop University, 57000, Sinop, Turkey

    Cumhur Avşar

  3. Department of Field Crops, Faculty of Agriculture, Hatay Mustafa Kemal University, 31060, Antakya, Hatay, Turkey

    Musa Turkmen

  4. Department of Medical Biology and Genetics, Faculty of Medicine, University of Gaziantep, 27300, Gaziantep, Turkey

    Sevgi Gezici

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  1. Faruk Karahan
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  2. Cumhur Avşar
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  3. Musa Turkmen
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  4. Sevgi Gezici
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  5. Ahmet Ilcim
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Correspondence to Faruk Karahan.

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Karahan, F., Avşar, C., Turkmen, M. et al. Comparative Study on Phytochemical Profiles, Antiproliferative, Antimicrobial and Antioxidant Activities of Adonis Species from Turkey. Pharm Chem J 56, 667–678 (2022). https://doi.org/10.1007/s11094-022-02693-0

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  • DOI: https://doi.org/10.1007/s11094-022-02693-0

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