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Extracts from the Liverwort Bazzania trilobata with Potential Dermo-cosmetic Properties

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Bioactive Compounds in Bryophytes and Pteridophytes

Part of the book series: Reference Series in Phytochemistry ((RSP))

Abstract

Bazzania trilobata (L.) Gray is a leafy liverwort from the family of Lepidoziaceae, well known for its antifungal properties. In this study, the 70% ethanol and methanol extracts of B. trilobata were investigated for new in vitro biological activities of cosmetic interest. The results showed that the total phenol content, the DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging activity, and the anti-collagenase activity of the 70% ethanol extract were higher than for methanol. The methanol extract showed mild tyrosinase inhibitory activity and antimicrobial properties towards the Gram-positive bacteria Enterococcus faecalis. Lignans, coumarins, and bis-bibenzyls were the major classes of phenolic constituents tentatively identified in both extracts. In addition, a known drimenyl caffeate was identified in B. trilobata and its structure was confirmed by NMR spectroscopy. These results suggest that extracts from B. trilobata could be exploited as an interesting new source of natural active ingredients for cosmetic applications.

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Abbreviations

COSY:

Homonuclear Correlation Spectroscopy

DPPH:

1-Diphenyl-2-picrylhydrazyl

GAE:

Gallic Acid Equivalents

HMBC:

Heteronuclear Multiple Bond Correlation

IC50:

Half Maximal Inhibitory Concentration

J:

Coupling Constant

MIC:

Minimum Inhibitory Concentration

MS/MS:

Tandem Mass Spectrometry

NMR:

Nuclear Magnetic Resonance

TPC:

Total Phenolic Content

UHPLC-HRMS:

Ultrahigh Performance Liquid Chromatography-High Resolution Mass Spectrometry

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Acknowledgments

This research was supported by Marie Sklodowska-Curie Actions Innovative Training Networks under the Horizon 2020 program under grant agreement n° 765115 – MossTech. The authors thank Professor Nils Cronberg, Lund University, Sweden, for support in plant identification and collection. The NMR Center • DTU and the Villum Foundation are acknowledged for access to the 800 MHz spectrometers.

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Authors and Affiliations

  1. Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark

    Raíssa Volpatto Marques, Yi Lu & Henrik Toft Simonsen

  2. Plant Advanced Technologies, Vandœuvre-lès-Nancy, France

    Aleksander Salwinski & Frédéric Bourgaud

  3. Department of Chemistry, Technical University of Denmark, Lyngby, Denmark

    Kasper Enemark-Rasmussen & Charlotte H. Gotfredsen

  4. Université de Lorraine, CNRS, Nancy, France

    Nicolas Hocquigny, Arnaud Risler & Raphaël E. Duval

  5. Faculté de Pharmacie, ABC Platform®, Vandœuvre-lès-Nancy, France

    Nicolas Hocquigny & Raphaël E. Duval

  6. Cellengo, Vandœuvre-lès-Nancy, France

    Sissi Miguel & Frédéric Bourgaud

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  1. Raíssa Volpatto Marques
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  2. Aleksander Salwinski
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Correspondence to Henrik Toft Simonsen .

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  1. Department of Botany, Karnatak University, Dharwad, Karnataka, India

    Hosakatte Niranjana Murthy

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Marques, R.V. et al. (2023). Extracts from the Liverwort Bazzania trilobata with Potential Dermo-cosmetic Properties. In: Murthy, H.N. (eds) Bioactive Compounds in Bryophytes and Pteridophytes. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-030-97415-2_9-1

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  • DOI: https://doi.org/10.1007/978-3-030-97415-2_9-1

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