Novel Pentacyclic seco-Prezizaane-Type Sesquiterpenoids with Neurotrophic Properties from Illicium jiadifengpi
Posted on 2009-11-19 - 00:00
Three novel seco-prezizaane-type sesquiterpenoids, jiadifenolide (1), jiadifenoxolane A (2), and jiadifenoxolane B (3), were isolated from the pericarps of Illicium jiadifengpi. Their pentacyclic cage structures were determined by 2D-NMR methods, chemical conversion, and single-crystal X-ray analysis. Compounds 1 and 2 strongly promote neurite outgrowth in primary cultured rat cortical neurons at concentrations ranging from 0.01 to 10 μM.
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Kubo, Miwa; Okada, Chihiro; Huang, Jian-Mei; Harada, Kenichi; Hioki, Hideaki; Fukuyama, Yoshiyasu (2016). Novel Pentacyclic seco-Prezizaane-Type Sesquiterpenoids with Neurotrophic Properties from Illicium jiadifengpi. ACS Publications. Collection. https://doi.org/10.1021/ol9021029
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AUTHORS (6)
MK
Miwa Kubo
CO
Chihiro Okada
JH
Jian-Mei Huang
KH
Kenichi Harada
HH
Hideaki Hioki
YF
Yoshiyasu Fukuyama