Research Article
Zeynep Akşit1,
Hüseyin Akşit2* and Ali Kandemir3
Abstract
The essential
oils from aerial parts of Ferulago setifolia K. Koch were
obtained by hydro-distillation and subjected to normal-phase-preparative-HPLC
(NP-p-HPLC) to yield highly pure α-pinene (1), sabinene (2), and
2,3,4-trimethyl benzaldehyde (3). The structures of isolates were
determined by GC/MS analysis. The isolated major components were subjected to
antimicrobial assay. The findings demonstrate that whereas the major
benzaldehyde molecule (3) has even less antibacterial action, the others
(1 and 2) exhibit strong antimicrobial activity. In this study, the antimicrobial activity of
individuals of Ferulago setifolia essential oil was first reported.
Abstract Keywords
Ferulago setifolia, antimicrobial activity, α-pinene,
sabinene, 2,3,4-trimethyl benzaldehyde, preparative-HPLC
Abstract
The essential
oils from aerial parts of Ferulago setifolia K. Koch were
obtained by hydro-distillation and subjected to normal-phase-preparative-HPLC
(NP-p-HPLC) to yield highly pure α-pinene (1), sabinene (2), and
2,3,4-trimethyl benzaldehyde (3). The structures of isolates were
determined by GC/MS analysis. The isolated major components were subjected to
antimicrobial assay. The findings demonstrate that whereas the major
benzaldehyde molecule (3) has even less antibacterial action, the others
(1 and 2) exhibit strong antimicrobial activity. In this study, the antimicrobial activity of
individuals of Ferulago setifolia essential oil was first reported.
Keywords
Ferulago setifolia, antimicrobial activity, α-pinene,
sabinene, 2,3,4-trimethyl benzaldehyde, preparative-HPLC
References
1. Karakaya,
S.; Şimşek, D.; Özbek, H.; Güvenalp, Z.; Altanlar, N.; Kazaz, C., et al. Antimicrobial
activities of extracts and isolated coumarins from the roots of four Ferulago
species growing in Turkey. Iran J. Pharm. Sci. 2019, 18, 1516-29
2. Jiménez, B.; Grande, M. C.; Anaya, J.;
Torres, P.; Grande, M. Coumarins from Ferulago capillaris and F.
brachyloba. Phytochemistry 2000,
53, 1025-31
3. Naseri, M.; Monsef-Esfehani, H.; Saeidnia,
S.; Dastan, D.; Gohari, A. Antioxidative coumarins from the roots of Ferulago
subvelutina. Asian J. Chem. 2013,
25, 1875-8
4. Khanahmadi, M.; Shahrezaei, F.; Alizadeh, A.
Isolation and structural elucidation of two flavonoids from Ferulago
angulata (Schlecht) Boiss. Asian J. Res. Chem. 2011, 4, 1667-70
5. Kızıltaş, H.; Bingol, Z.; Gören, A. C.; Kose,
L. P.; Durmaz, L.; Topal, F., et al. LC-HRMS Profiling and Antidiabetic,
Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago
stellata). Molecules. 2021, 26,
2469-78
6. Ruberto, G.; Biondi, D.; Renda, A. The
composition of the volatile oil of Ferulago nodosa obtained by steam
distillation and supercritical carbon dioxide extraction. Phytochem. Anal. 1999, 10, 241-6
7. Demirci, F.; İşcan, G.; Güven, K.; Başer, K.
H. C. Antimicrobial Activities of Ferulago Essential Oils. Z.
Naturforsch C. J. Biosci. 2000, 55,
886-9
8. Khalighi, S. F.; Haji, A. A.; Shahverdi, A.
R.; Mozafarian, V.; Shafiei, A. Chemical composition and antimicrobial activity
of the essential oil of Ferulago bernardii Tomk. and M. pimen.
DARU J. Pharm. Sci. 2005, 13, 100-4
9. Kılıç, C. S.; Özkan, A. M. G.; Demirci, B.;
Coşkun, M.; Başer, K. H. C. Essential oil composition of four endemic Ferulago
species growing in Turkey. Nat. Prod. Commun. 2010, 5, 1951-4
10. Sanli, A.; Karadogan, T.; Tosun, B.; Erbas, S.
Variation of Chemical Composition of Essential Oils in Wild Populations of Ferulago
cassia Boiss. From Turkey. J. Essent. Oil-Bear. Plants. 2020, 23, 1386-94
11. Sajjadi, S.; Shokoohinia, Y.; Jamali, M.
Chemical composition of essential oil of Ferulago macrocarpa (Fenzl)
Boiss. fruits. Res. Pharm. Sci. 2012,
7, 197-204
12. Stamenković, J. G.; Petrović, G. M.; Jovanović,
O. P.; Ickovski, J. D.; Palić, I. R.; Stojanović, G. S. Chemical composition of
the essential oils and headspace volatiles of Ferulago sylvatica
(Besser) Reichenb. from Serbia. Nat. Prod. Res. 2020, 34, 1947-50
13. Rivas da Silva, A. C.; Lopes, P. M.; Barros de
Azevedo, M. M.; Costa, D.; Alviano, C. S.; Alviano, D. S. Biological activities
of α-pinene and β-pinene enantiomers. Molecules. 2012, 17, 6305-16
14. Sieniawska, E.; Los, R.; Baj, T.; Malm, A.;
Glowniak, K. Antimicrobial efficacy of Mutellina purpurea essential oil and
α-pinene against Staphylococcus epidermidis grown in planktonic and biofilm
cultures. Ind. Crops Prod. 2013, 51,
152-7
15. Arunkumar, R.; Nair, S. A.; Rameshkumar, K. B.;
Subramoniam, A. The essential oil constituents of Zornia diphylla (L.)
Pers, and anti-inflammatory and antimicrobial activities of the oil. Rec. Nat.
Prod. 2014, 8, 385
16. Zhou, S.; Wei, C.; Zhang, C.; Han, C.;
Kuchkarova, N.; Shao, H. Chemical composition, phytotoxic, antimicrobial and
insecticidal activity of the essential oils of Dracocephalum integrifolium.
Toxins. 2019, 11, 598.
This work is licensed under the
Creative Commons Attribution
4.0
License (CC BY-NC 4.0).
Abstract
The essential
oils from aerial parts of Ferulago setifolia K. Koch were
obtained by hydro-distillation and subjected to normal-phase-preparative-HPLC
(NP-p-HPLC) to yield highly pure α-pinene (1), sabinene (2), and
2,3,4-trimethyl benzaldehyde (3). The structures of isolates were
determined by GC/MS analysis. The isolated major components were subjected to
antimicrobial assay. The findings demonstrate that whereas the major
benzaldehyde molecule (3) has even less antibacterial action, the others
(1 and 2) exhibit strong antimicrobial activity. In this study, the antimicrobial activity of
individuals of Ferulago setifolia essential oil was first reported.
Abstract Keywords
Ferulago setifolia, antimicrobial activity, α-pinene,
sabinene, 2,3,4-trimethyl benzaldehyde, preparative-HPLC
This work is licensed under the
Creative Commons Attribution
4.0
License (CC BY-NC 4.0).
Editor-in-Chief
This work is licensed under the
Creative Commons Attribution 4.0
License.(CC BY-NC 4.0).